||This article needs more medical references for verification or relies too heavily on primary sources. (July 2012)|
Deuterium-depleted water (DDW), also known more ambiguously as light water, is water which has a lower concentration of deuterium than occurs naturally. Deuterium a heavier isotope of hydrogen which has, in addition to its one proton, a neutron, that roughly doubles the mass of the hydrogen atom.
In Vienna Standard Mean Ocean Water, deuterium occurs at a rate of 155.76 ppm. The production of heavy water involves isolating and removing deuterium within water. The by-product of this process is light water. Production of light water can result during electrolysis, distillation, and desalination. It can also be produced directly using the Girdler sulfide process.
Experiments have shown that consumption of light water may be beneficial as an adjunct to chemotherapy. A 1999 Romanian study found that water with only 30 ppm deuterium produced marked improvement in survival rates of mice bombarded with ionizing radiation. A study of four patients with brain metastases from lung cancer found a three-month regimen of light water "noticeably prolonged" their survival time. A 2010 Hungarian study found significant improvement in the survival times of prostate cancer patients treated with light water. Despite Gilbert Lewis' call in 1934 for such experiments., research on the effects of deuterium-depletion on living cells has been very limited with less than a dozen peer-reviewed research papers available via PubMed in mid-2011
Depleted water (125 ppm deuterium corresponds to the deuterium:protium ratio D:H=1:7695) at a consumption as high as 2 litres per day can influence the deuterium concentration in human body (average 40 litres with deuterium:protium ratio about D:H = 1:6418) for less than 1% (decreasing the normal ratio to D:H = 1:6472). A 1963 American paper is reported to infer that no biological effect should be expected at this level,  though new researches are currently carried on in eastern Europe.
- Boyle, Rebecca (6 Jan 2011). "With New Method, China Can Mass-Produce Light Water For Its Citizens' Thirst". Popular Science. Retrieved 7 Jan 2011.
- Bild, W; Stefanescu, I; Haulica, I; Lupuşoru, C; Titescu, G; Iliescu, R; Nastasa, V (1999). "Research concerning the radioprotective and immunostimulating effects of deuterium-depleted water". Romanian journal of physiology 36 (3-4): 205–18. PMID 11797936.
- Krempels, Krisztina; Somlyai, Ildikó; Somlyai, Gábor (2008). "A Retrospective Evaluation of the Effects of Deuterium Depleted Water Consumption on 4 Patients with Brain Metastases from Lung Cancer". Integrative Cancer Therapies 7 (3): 172–81. doi:10.1177/1534735408322851. PMID 18815148.
- Somlyai, Gábor; Molnár, Miklós; Laskay, Gábor; Szabó, M; Berkényi, Tamás; Guller, Imre; Kovács, András (2010). "A természetben megtalálható deutérium biológiai jelentősége: a deutériumdepletio daganatellenes hatása" [Biological Significance of Naturally Occurring Deuterium: the Antitumor Effect of Deuterium Depletion]. Orvosi Hetilap (in Hungarian) 151 (36): 1455–60. doi:10.1556/OH.2010.28865. PMID 20739263.
- Lewis, G. N. (1934). "THE BIOLOGY OF HEAVY WATER". Science 79 (2042): 151–153. Bibcode:1934Sci....79..151L. doi:10.1126/science.79.2042.151. PMID 17788137.
- Koch, Steven J. (4 March 2011). "I am maximally-skeptical that there currently exists any evidence that drinking deuterium-depleted water has health benefits or will cure disease". Blogspot.com. Retrieved 22 July 2011.
- Thompson, J.F.: Biological effects of deuterium, Pergamon Press, New York 1963.