EGOT (gene)

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Eosinophil granule ontogeny transcript (non-protein coding)
Identifiers
Symbols EGOT ; EGO; NCRNA00190
External IDs OMIM611662 GeneCards: EGOT Gene
Orthologs
Species Human Mouse
Entrez 100126791 n/a
Ensembl ENSG00000235947 n/a
UniProt n/a n/a
RefSeq (mRNA) NR_004428 n/a
RefSeq (protein) n/a n/a
Location (UCSC) Chr 3:
4.79 – 4.79 Mb
n/a
PubMed search [1] n/a

EGOT, also known as Eosinophil Granule Ontogeny (EGO)† Transcript (non-protein coding),[1] is a human gene at 3p26.1 encoding a long noncoding RNA molecule. EGOT is nested within an intron of the inositol triphosphate receptor type 1 (ITPR1) gene. The EGOT transcript is expressed during eosinophil development and is possibly involved in regulating eosinophil granule protein expression.[1] Comparison of EGO-B, the spliced isoform, suggests EGOT may be conserved across placental mammals.[2]

†Originally published as EGO but renamed as EGOT because 'EGO' is a real word and is therefore problematic when searching the scientific literature.[3]

References[edit]

  1. ^ a b Wagner LA, Christensen CJ, Dunn DM, et al. (June 2007). "EGO, a novel, noncoding RNA gene, regulates eosinophil granule protein transcript expression". Blood 109 (12): 5191–8. doi:10.1182/blood-2006-06-027987. PMC 1890841. PMID 17351112. 
  2. ^ Rose D, Stadler PF (October 2011). "Molecular evolution of the non-coding eosinophil granule ontogeny transcript". Front Genet 2. doi:10.3389/fgene.2011.00069. PMC 3268622. PMID 22303364. 
  3. ^ Wright, MW (Apr 9, 2014). "A short guide to long non-coding RNA gene nomenclature.". Human genomics 8: 7. PMID 24716852.