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Inositol 1,4,5-trisphosphate receptor, type 1
PBB Protein ITPR1 image.jpg
PDB rendering based on 1n4k.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ITPR1 ; ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94; SCA15; SCA16; SCA29
External IDs OMIM147265 MGI96623 HomoloGene1673 IUPHAR: 743 ChEMBL: 4046 GeneCards: ITPR1 Gene
RNA expression pattern
PBB GE ITPR1 203710 at tn.png
PBB GE ITPR1 211323 s at tn.png
PBB GE ITPR1 216944 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3708 16438
Ensembl ENSG00000150995 ENSMUSG00000030102
UniProt Q14643 P11881
RefSeq (mRNA) NM_001099952 NM_010585
RefSeq (protein) NP_001093422 NP_034715
Location (UCSC) Chr 3:
4.54 – 4.89 Mb
Chr 6:
108.21 – 108.55 Mb
PubMed search [1] [2]

Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ITPR1 gene.[1][2][3][4][5]


ITPR1 has been shown to interact with CA8,[6] PRKG1,[7] FKBP1A,[8][9] MRVI1,[7] RHOA,[10] AHCYL1,[11] EPB41L1[12] and TRPC4.[13][14]

See also[edit]


  1. ^ Yamada N, Makino Y, Clark RA, Pearson DW, Mattei MG, Guenet JL, Ohama E, Fujino I, Miyawaki A, Furuichi T et al. (October 1994). "Human inositol 1,4,5-trisphosphate type-1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization". Biochem J 302 (Pt 3): 781–90. PMC 1137299. PMID 7945203. 
  2. ^ Nucifora FC Jr, Li SH, Danoff S, Ullrich A, Ross CA (January 1996). "Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant". Brain Res Mol Brain Res 32 (2): 291–6. doi:10.1016/0169-328X(95)00089-B. PMID 7500840. 
  3. ^ van de Leemput J, Chandran J, Knight MA, Holtzclaw LA, Scholz S, Cookson MR, Houlden H, Gwinn-Hardy K, Fung HC, Lin X, Hernandez D, Simon-Sanchez J, Wood NW, Giunti P, Rafferty I, Hardy J, Storey E, Gardner RJ, Forrest SM, Fisher EM, Russell JT, Cai H, Singleton AB (August 2007). "Deletion at ITPR1 Underlies Ataxia in Mice and Spinocerebellar Ataxia 15 in Humans". PLoS Genet 3 (6): e108. doi:10.1371/journal.pgen.0030108. PMC 1892049. PMID 17590087. 
  4. ^ Iwaki A, Kawano Y, Miura S, Shibata H, Matsuse D, Li W, Furuya H, Ohyagi Y, Taniwaki T, Kira J, Fukumaki Y (January 2008). "Heterozygous deletion of ITPR1, but not SUMF1, in spinocerebellar ataxia type 16". J Med Genet 45 (1): 32–5. doi:10.1136/jmg.2007.053942. PMID 17932120. 
  5. ^ "Entrez Gene: ITPR1 inositol 1,4,5-triphosphate receptor, type 1". 
  6. ^ Hirota, Junji; Ando Hideaki; Hamada Kozo; Mikoshiba Katsuhiko (June 2003). "Carbonic anhydrase-related protein is a novel binding protein for inositol 1,4,5-trisphosphate receptor type 1". Biochem. J. (England) 372 (Pt 2): 435–41. doi:10.1042/BJ20030110. ISSN 0264-6021. PMC 1223404. PMID 12611586. 
  7. ^ a b Schlossmann, J; Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang G X, Allescher H D, Korth M, Wilm M, Hofmann F, Ruth P (March 2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature (ENGLAND) 404 (6774): 197–201. doi:10.1038/35004606. ISSN 0028-0836. PMID 10724174. 
  8. ^ MacMillan, Debbi; Currie Susan; Bradley Karen N; Muir Thomas C; McCarron John G (December 2005). "In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin". J. Cell. Sci. (England) 118 (Pt 23): 5443–51. doi:10.1242/jcs.02657. ISSN 0021-9533. PMID 16278292. 
  9. ^ Cameron, A M; Nucifora F C; Fung E T; Livingston D J; Aldape R A; Ross C A; Snyder S H (October 1997). "FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain". J. Biol. Chem. (UNITED STATES) 272 (44): 27582–8. doi:10.1074/jbc.272.44.27582. ISSN 0021-9258. PMID 9346894. 
  10. ^ Mehta, Dolly; Ahmmed Gias U, Paria Biman C, Holinstat Michael, Voyno-Yasenetskaya Tatyana, Tiruppathi Chinnaswamy, Minshall Richard D, Malik Asrar B (August 2003). "RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability". J. Biol. Chem. (United States) 278 (35): 33492–500. doi:10.1074/jbc.M302401200. ISSN 0021-9258. PMID 12766172. 
  11. ^ Ando, Hideaki; Mizutani Akihiro, Matsu-ura Toru, Mikoshiba Katsuhiko (March 2003). "IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor". J. Biol. Chem. (United States) 278 (12): 10602–12. doi:10.1074/jbc.M210119200. ISSN 0021-9258. PMID 12525476. 
  12. ^ Maximov, Anton; Tang Tie Shan; Bezprozvanny Ilya (February 2003). "Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons". Mol. Cell. Neurosci. (United States) 22 (2): 271–83. doi:10.1016/S1044-7431(02)00027-1. ISSN 1044-7431. PMID 12676536. 
  13. ^ Yuan, Joseph P; Kiselyov Kirill, Shin Dong Ming, Chen Jin, Shcheynikov Nikolay, Kang Shin H, Dehoff Marlin H, Schwarz Martin K, Seeburg Peter H, Muallem Shmuel, Worley Paul F (September 2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell (United States) 114 (6): 777–89. doi:10.1016/S0092-8674(03)00716-5. ISSN 0092-8674. PMID 14505576. 
  14. ^ Mery, L; Magnino F; Schmidt K; Krause K H; Dufour J F (January 2001). "Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors". FEBS Lett. (Netherlands) 487 (3): 377–83. doi:10.1016/S0014-5793(00)02362-0. ISSN 0014-5793. PMID 11163362. 

Further reading[edit]

  • Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects". Curr. HIV Res. 4 (1): 57–64. doi:10.2174/157016206775197583. PMID 16454711. 
  • Joseph SK, Lin C, Pierson S et al. (1995). "Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells". J. Biol. Chem. 270 (40): 23310–6. doi:10.1074/jbc.270.40.23310. PMID 7559486. 
  • Harnick DJ, Jayaraman T, Ma Y et al. (1995). "The human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylation". J. Biol. Chem. 270 (6): 2833–40. doi:10.1074/jbc.270.6.2833. PMID 7852357. 
  • Wojcikiewicz RJ, Furuichi T, Nakade S et al. (1994). "Muscarinic receptor activation down-regulates the type I inositol 1,4,5-trisphosphate receptor by accelerating its degradation". J. Biol. Chem. 269 (11): 7963–9. PMID 8132516. 
  • Komalavilas P, Lincoln TM (1994). "Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase". J. Biol. Chem. 269 (12): 8701–7. PMID 8132598. 
  • Cameron AM, Steiner JP, Roskams AJ et al. (1996). "Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux". Cell 83 (3): 463–72. doi:10.1016/0092-8674(95)90124-8. PMID 8521476. 
  • Yan J, Khanna KK, Lavin MF (1996). "Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation". Int. J. Radiat. Biol. 69 (5): 539–46. doi:10.1080/095530096145544. PMID 8648241. 
  • Quinton TM, Dean WL (1996). "Multiple inositol 1,4,5-trisphosphate receptor isoforms are present in platelets". Biochem. Biophys. Res. Commun. 224 (3): 740–6. doi:10.1006/bbrc.1996.1093. PMID 8713116. 
  • Cameron AM, Nucifora FC, Fung ET et al. (1997). "FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain". J. Biol. Chem. 272 (44): 27582–8. doi:10.1074/jbc.272.44.27582. PMID 9346894. 
  • Deelman LE, Jonk LJ, Henning RH (1998). "The isolation and characterization of the promoter of the human type 1 inositol 1,4,5-trisphosphate receptor". Gene 207 (2): 219–25. doi:10.1016/S0378-1119(97)00630-6. PMID 9511764. 
  • Martin C, Chapman KE, Seckl JR, Ashley RH (1998). "Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum". Neuroscience 85 (1): 205–16. doi:10.1016/S0306-4522(97)00612-X. PMID 9607712. 
  • Tu JC, Xiao B, Yuan JP et al. (1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron 21 (4): 717–26. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459. 
  • Kiselyov K, Xu X, Mozhayeva G et al. (1998). "Functional interaction between InsP3 receptors and store-operated Htrp3 channels". Nature 396 (6710): 478–82. doi:10.1038/24890. PMID 9853757. 
  • Lin P, Yao Y, Hofmeister R et al. (1999). "Overexpression of CALNUC (Nucleobindin) Increases Agonist and Thapsigargin Releasable Ca2+ Storage in the Golgi". J. Cell Biol. 145 (2): 279–89. doi:10.1083/jcb.145.2.279. PMC 2133108. PMID 10209024. 
  • Schlossmann J, Ammendola A, Ashman K et al. (2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature 404 (6774): 197–201. doi:10.1038/35004606. PMID 10724174. 
  • Dias Neto E, Correa RG, Verjovski-Almeida S et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800. 
  • Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". J. Immunol. 164 (12): 6538–42. doi:10.4049/jimmunol.164.12.6538. PMID 10843712. 
  • Tanimura A, Tojyo Y, Turner RJ (2000). "Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins". J. Biol. Chem. 275 (35): 27488–93. doi:10.1074/jbc.M004495200. PMID 10874040. 

External links[edit]