FBXL5

FBXL5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3U9J, 3U9M, 3V5X, 3V5Y, 3V5Z
Identifiers
Aliases	FBXL5, FBL4, FBL5, FLR1, F-box and leucine-rich repeat protein 5, F-box and leucine rich repeat protein 5
External IDs	OMIM: 605655; MGI: 2152883; HomoloGene: 8129; GeneCards: FBXL5; OMA:FBXL5 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4p15.32 Start 15,604,381 bp End 15,681,679 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 B3 Start 43,901,957 bp End 43,978,980 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte Epithelium of choroid plexus Achilles tendon kidney tubule blood seminal vesicula germinal epithelium oocyte secondary oocyte sperm Top expressed in spermatocyte granulocyte otolith organ utricle spermatid neural layer of retina lobe of cerebellum gastrula cerebellar vermis habenula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function iron ion binding protein binding metal ion binding ubiquitin-protein transferase activity Cellular component ubiquitin ligase complex cytoplasm SCF ubiquitin ligase complex perinuclear region of cytoplasm cytosol Biological process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process protein ubiquitination iron ion homeostasis protein polyubiquitination cellular iron ion homeostasis post-translational protein modification ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26234 242960 Ensembl ENSG00000118564 ENSMUSG00000039753 UniProt Q9UKA1 Q8C2S5 RefSeq (mRNA) NM_001193534 NM_001193535 NM_012161 NM_001159963 NM_178729 RefSeq (protein) NP_001180463 NP_001180464 NP_036293 NP_001153435 NP_848844 Location (UCSC) Chr 4: 15.6 – 15.68 Mb Chr 5: 43.9 – 43.98 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

F-box/LRR-repeat protein 5 is a protein that in humans is encoded by the FBXL5 gene.

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternative splicing of this gene generates 2 transcript variants.

FBXL5 is an iron sensor. It promotes IRP2 ubiquitination and then its degradation.

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins". Curr. Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.
• Ilyin GP, Rialland M, Pigeon C, Guguen-Guillouzo C (2001). "cDNA cloning and expression analysis of new members of the mammalian F-box protein family". Genomics. 67 (1): 40–7. doi:10.1006/geno.2000.6211. PMID 10945468.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Zhang N, Liu J, Ding X, et al. (2007). "FBXL5 interacts with p150Glued and regulates its ubiquitination". Biochem. Biophys. Res. Commun. 359 (1): 34–9. doi:10.1016/j.bbrc.2007.05.068. PMID 17532294.