From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
FUN14 domain containing 1 is a protein that in humans is encoded by the FUNDC1 gene .[ 5]
Model organisms
Model organisms have been used in the study of FUNDC1 function. A conditional knockout mouse line, called Fundc1tm1a(KOMP)Wtsi [ 10] [ 11] International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute .[ 12] [ 13] [ 14]
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[ 8] [ 15] mutant mice, however no significant abnormalities were observed.[ 8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000069509 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025040 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: FUN14 domain containing 1" . Retrieved 2011-09-19 .^ "Salmonella infection data for Fundc1" . Wellcome Trust Sanger Institute.^ "Citrobacter infection data for Fundc1" . Wellcome Trust Sanger Institute.^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica . 88 (S248). doi :10.1111/j.1755-3768.2010.4142.x . S2CID 85911512 . ^ Mouse Resources Portal , Wellcome Trust Sanger Institute.^ "International Knockout Mouse Consortium" .^ "Mouse Genome Informatics" .^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function" . Nature . 474 (7351): 337–342. doi :10.1038/nature10163 . PMC 3572410 PMID 21677750 . ^ Dolgin E (June 2011). "Mouse library set to be knockout" . Nature . 474 (7351): 262–3. doi :10.1038/474262a PMID 21677718 . ^ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons" . Cell . 128 (1): 9–13. doi :10.1016/j.cell.2006.12.018 PMID 17218247 . S2CID 18872015 . ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism" . Genome Biol . 12 (6): 224. doi :10.1186/gb-2011-12-6-224 . PMC 3218837 PMID 21722353 . {{cite journal }}: CS1 maint: unflagged free DOI (link )
Further reading
Terracciano, A.; Sanna, S.; Uda, M.; Deiana, B.; Usala, G.; Busonero, F.; Maschio, A.; Scally, M.; Patriciu, N.; Chen, W. -M.; Distel, M. A.; Slagboom, E. P.; Boomsma, D. I.; Villafuerte, S.; Sliwerska, E.; Burmeister, M.; Amin, N.; Janssens, A. C. J. W.; Van Duijn, C. M.; Schlessinger, D.; Abecasis, G. R.; Costa Jr, P. T. (2008). "Genome-wide association scan for five major dimensions of personality" . Molecular Psychiatry . 15 (6): 647–656. doi :10.1038/mp.2008.113 . PMC 2874623 PMID 18957941 .
