Falcarindiol

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Falcarindiol
Falcarindiol.svg
Identifiers
CAS number 55297-87-5 YesY
PubChem 5281148
ChemSpider 4444588
ChEMBL CHEMBL69018
Jmol-3D images Image 1
Properties
Molecular formula C17H24O2
Molar mass 260.371
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Falcarindiol is a polyacetylene found in carrot roots which has antifungal activity.[1][2] Falcarindiol is the main compound responsible for bitterness in carrots.[3] Falcarindiol and other falcarindiol-type polyacetylenes are also found in many other plants of the Apiaceae family, including some commonly used seasonings such as dill and parsley.[4] A variety of bioactivities have been reported so far for falcaridiol and the falcarindiol-type polyacetylenes,[5][6][7] and because of potential health-promoting metabolic effects these compounds are studied as potential nutraceuticals.[8]

See also[edit]

References[edit]

  1. ^ Garrod, B. (1978). "Cis-heptadeca-1,9-diene-4,6-diyne-3,8-diol, an antifungal polyacetylene from carrot root tissue". Physiologial Plant Pathology 13 (2): 241–246. doi:10.1016/0048-4059(78)90039-5. 
  2. ^ Kemp, M. S. (1978). "Falcarindiol: An antifungal polyacetylene from Aegopodium podagraria". Phytochemistry 17 (5): 1002. doi:10.1016/S0031-9422(00)88669-0. 
  3. ^ Czepa, A.; Hofmann, T. (2003). "Structural and sensory characterization of compounds contributing to the bitter off-taste of carrots (Daucus carota L.) and carrot puree". Journal of Agricultural and Food Chemistry 51 (13): 3865–3873. doi:10.1021/jf034085+. PMID 12797757. 
  4. ^ Christensen, L. P.; Brandt, K. (2006). "Bioactive polyacetylenes in food plants of the Apiaceae family: Occurrence, bioactivity and analysis". Journal of Pharmaceutical and Biomedical Analysis 41 (3): 683–693. doi:10.1016/j.jpba.2006.01.057. PMID 16520011. 
  5. ^ Atanasov, A. G.; Blunder, M.; Fakhrudin, N.; Liu, X.; Noha, S. M.; Malainer, C.; Kramer, M. P.; Cocic, A.; Kunert, O.; Schinkovitz, A.; Heiss, E. H.; Schuster, D.; Dirsch, V. M.; Bauer, R. (2013). "Polyacetylenes from Notopterygium incisum - new selective partial agonists of peroxisome proliferator-activated receptor-gamma". PLoS ONE 8 (4): e61755. doi:10.1371/journal.pone.0061755. PMC 3632601. PMID 23630612. 
  6. ^ Jin, H. R.; Zhao, J.; Zhang, Z.; Liao, Y.; Wang, C. Z.; Huang, W. H.; Li, S. P.; He, T. C.; Yuan, C. S.; Du, W. (2012). "The antitumor natural compound falcarindiol promotes cancer cell death by inducing endoplasmic reticulum stress". Cell Death and Disease 3 (8): e376. doi:10.1038/cddis.2012.122. PMC 3434669. PMID 22914324. 
  7. ^ Wyrembek, P.; Negri, R.; Kaczor, P.; Czyżewska, M.; Appendino, G.; Mozrzymas, J. W. (2012). "Falcarindiol allosterically modulates GABAergic currents in cultured rat hippocampal neurons". Journal of Natural Products 75 (4): 610–616. doi:10.1021/np2008522. PMID 22432736. 
  8. ^ Christensen, L. P. (2011). "Aliphatic C17-Polyacetylenes of the Falcarinol Type as Potential Health Promoting Compounds in Food Plants of the Apiaceae Family". Recent Patents on Food, Nutrition and Agriculture 3 (1): 64–77. doi:10.2174/2212798411103010064. PMID 21114468.