State Road 405 (SR 405) is a state highway making a sweeping arc in Titusville, Florida, and providing a major access route for the Kennedy Space Center on nearby Merritt Island. The northern terminus of SR 405 is an intersection with North Washington Avenue (US 1-SR 5) in downtown Titusville; the eastern terminus is at the Space Center entrance just west of County Road 3. It is locally known as South Street, Columbia Boulevard, and the NASA Causeway.
South of Cheney Highway (SR 50), SR 405 is signed east–west; north of SR 50, SR 405 is signed north–south. It parallels Interstate 95 (SR 9) for 2.2 miles (3.5 km) - from Cheney Highway to Willis Drive - before veering off the northeast to become the residential South Street.