Fort Defiance was rated Fully Accredited by the Virginia Department of Education in the 2005-2006 and 2006-2007 school years. Students scored above state average on all 2006 Standards of Learning tests.  In 2006, students from Fort Defiance won the International Canon Envirothon.  Fort Defiance offers numerous AP courses to students. Dual Enrollment courses are also offered through Blue Ridge Community College in nearby Weyers Cave, VA. These courses allow students to earn college credit while still attending high school. The foreign languages offered at Fort Defiance are Spanish, Latin, and French. Students must take at least two years of two languages or three years of one.
Fort Defiance has won many district championships, and a few state championships. The Girls' Tennis team won the 1998, 1996, and 1989 AA Virginia High School League State Tennis Championships. The Girls' tennis team won the 1987, 1988, 1990, and 1995 Virginia High School League State Winter Tennis Championships. The Boys' Cross Country Team won the 2003 AA State Championships and were runner up in the 2004 AA State Championships. The school is well known for Dell Curry, a former NBA player, and Jackie Curry-Lynch from "The John Boy and Billy Show".