Most of Eyton's work was collaborations with Noel Gay and Billy Mayerl in London-based musical theatre. With Mayerl as composer, Eyton co-wrote with Desmond Carter the lyrics for the celebrated sequence "Side by Side" from Over She Goes (filmed 1938). His most successful play was the 1948 musical farce, Bob's Your Uncle, written in collaboration with Gay.
Eyton wrote the music for the 1942 film Let the People Sing. He was also one of the soundtrack writers of Body and Soul, a successful boxing film from 1947.