GEFT

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Rho guanine nucleotide exchange factor (GEF) 25
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ARHGEF25 ; GEFT; p63RhoGEF
External IDs OMIM610215 MGI1277173 HomoloGene32691 GeneCards: ARHGEF25 Gene
Orthologs
Species Human Mouse
Entrez 115557 52666
Ensembl ENSG00000240771 ENSMUSG00000019467
UniProt Q86VW2 Q9CWR0
RefSeq (mRNA) NM_001111270 NM_001166413
RefSeq (protein) NP_001104740 NP_001159885
Location (UCSC) Chr 12:
58 – 58.01 Mb
Chr 10:
127.18 – 127.19 Mb
PubMed search [1] [2]

RAC/CDC42 exchange factor, also known as GEFT, is a human gene.[1]

Interactions[edit]

GEFT has been shown to interact with RHOA.[2]

References[edit]

  1. ^ "Entrez Gene: GEFT RAC/CDC42 exchange factor". 
  2. ^ Lutz S, Freichel-Blomquist A, Rümenapp U, Schmidt M, Jakobs K, Wieland T (May 2004). "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene". Naunyn Schmiedebergs Arch. Pharmacol. 369 (5): 540–6. doi:10.1007/s00210-004-0926-5. PMID 15069594. 

Further reading[edit]

  • Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance M, Vettel C et al. (2008). "Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.". Science 318 (5858): 1923–7. doi:10.1126/science.1147554. PMID 18096806. 
  • Bryan B, Cai Y, Liu M (2006). "The Rho-family guanine nucleotide exchange factor GEFT enhances retinoic acid- and cAMP-induced neurite outgrowth.". J. Neurosci. Res. 83 (7): 1151–9. doi:10.1002/jnr.20814. PMID 16496360. 
  • Bryan B, Mitchell D, Zhao L, Ma W, Stafford L, Teng B et al. (2006). "Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT.". Mol. Cell. Biol. 25 (24): 11089–101. doi:10.1128/MCB.25.24.11089-11101.2005. PMC 1316953. PMID 16314529. 
  • Lutz S, Freichel-Blomquist A, Yang Y, Rümenapp U, Jakobs K, Schmidt M et al. (2005). "The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA.". J. Biol. Chem. 280 (12): 11134–9. doi:10.1074/jbc.M411322200. PMID 15632174. 
  • Bryan B, Kumar V, Stafford L, Cai Y, Wu G, Liu M (2004). "GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation.". J. Biol. Chem. 279 (44): 45824–32. doi:10.1074/jbc.M406216200. PMID 15322108. 
  • Lutz S, Freichel-Blomquist A, Rümenapp U, Schmidt M, Jakobs K, Wieland T (2004). "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene.". Naunyn Schmiedebergs Arch. Pharmacol. 369 (5): 540–6. doi:10.1007/s00210-004-0926-5. PMID 15069594. 
  • Guo X, Stafford L, Bryan B, Xia C, Ma W, Wu X et al. (2003). "A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration.". J. Biol. Chem. 278 (15): 13207–15. doi:10.1074/jbc.M208896200. PMID 12547822. 
  • Souchet M, Portales-Casamar E, Mazurais D, Schmidt S, Léger I, Javré J et al. (2002). "Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere.". J. Cell. Sci. 115 (Pt 3): 629–40. PMID 11861769.