GEFT

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Rho guanine nucleotide exchange factor (GEF) 25
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ARHGEF25 ; GEFT; p63RhoGEF
External IDs OMIM610215 MGI1277173 HomoloGene32691 GeneCards: ARHGEF25 Gene
Orthologs
Species Human Mouse
Entrez 115557 52666
Ensembl ENSG00000240771 ENSMUSG00000019467
UniProt Q86VW2 Q9CWR0
RefSeq (mRNA) NM_001111270 NM_001166413
RefSeq (protein) NP_001104740 NP_001159885
Location (UCSC) Chr 12:
58 – 58.01 Mb
Chr 10:
127.18 – 127.19 Mb
PubMed search [1] [2]

RAC/CDC42 exchange factor, also known as GEFT, is a human gene.[1]

Interactions[edit]

GEFT has been shown to interact with RHOA.[2]

References[edit]

  1. ^ "Entrez Gene: GEFT RAC/CDC42 exchange factor". 
  2. ^ Lutz S, Freichel-Blomquist A, Rümenapp U, Schmidt M, Jakobs KH, Wieland T (May 2004). "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene". Naunyn Schmiedebergs Arch. Pharmacol. 369 (5): 540–6. doi:10.1007/s00210-004-0926-5. PMID 15069594. 

Further reading[edit]

  • Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C et al. (2008). "Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.". Science 318 (5858): 1923–7. doi:10.1126/science.1147554. PMID 18096806. 
  • Bryan BA, Cai Y, Liu M (2006). "The Rho-family guanine nucleotide exchange factor GEFT enhances retinoic acid- and cAMP-induced neurite outgrowth.". J. Neurosci. Res. 83 (7): 1151–9. doi:10.1002/jnr.20814. PMID 16496360. 
  • Bryan BA, Mitchell DC, Zhao L, Ma W, Stafford LJ, Teng BB et al. (2006). "Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT.". Mol. Cell. Biol. 25 (24): 11089–101. doi:10.1128/MCB.25.24.11089-11101.2005. PMC 1316953. PMID 16314529. 
  • Lutz S, Freichel-Blomquist A, Yang Y, Rümenapp U, Jakobs KH, Schmidt M et al. (2005). "The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA.". J. Biol. Chem. 280 (12): 11134–9. doi:10.1074/jbc.M411322200. PMID 15632174. 
  • Bryan B, Kumar V, Stafford LJ, Cai Y, Wu G, Liu M (2004). "GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation.". J. Biol. Chem. 279 (44): 45824–32. doi:10.1074/jbc.M406216200. PMID 15322108. 
  • Lutz S, Freichel-Blomquist A, Rümenapp U, Schmidt M, Jakobs KH, Wieland T (2004). "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene.". Naunyn Schmiedebergs Arch. Pharmacol. 369 (5): 540–6. doi:10.1007/s00210-004-0926-5. PMID 15069594. 
  • Guo X, Stafford LJ, Bryan B, Xia C, Ma W, Wu X et al. (2003). "A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration.". J. Biol. Chem. 278 (15): 13207–15. doi:10.1074/jbc.M208896200. PMID 12547822. 
  • Souchet M, Portales-Casamar E, Mazurais D, Schmidt S, Léger I, Javré JL et al. (2002). "Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere.". J. Cell. Sci. 115 (Pt 3): 629–40. PMID 11861769.