Gattermann–Koch reaction
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The Gattermann–Koch reaction, named after the German chemists Ludwig Gattermann and Julius Arnold Koch,[1] in organic chemistry refers to a Friedel–Crafts acylation reaction in which carbon monoxide and hydrochloric acid are used in situ with Friedel–Crafts catalyst, namely AlCl3 to produce a benzaldehyde derivative from a benzene derivative in one step.[2] Benzaldehyde and many aromatic aldehydes are conveniently synthesized by this reaction. Presence of traces of copper(I) chloride are also needed.
An example would be the conversion of toluene to p-tolualdehyde.[3]
[edit] See also
[edit] References
- ^ Gattermann, L.; Koch, J. A. (1897). "Eine Synthese aromatischer Aldehyde". Ber. 30: 1622. doi:10.1002/cber.18970300288.
- ^ LI Jie Jack (2003) (available on Google Books). Name Reactions: A Collection of Detailed Reaction Mechanisms (2nd ed.). Springer. p. 157. ISBN 3540402039. http://books.google.com/?id=6mZJ3084ouAC&pg=PA157&lpg=PA157&dq=%22gattermann+koch%22+reaction.
- ^ G. H. Coleman, David Craig (1943), "p-Tolualdehyde", Org. Synth., http://www.orgsyn.org/orgsyn/orgsyn/prepContent.asp?prep=cv2p0583; Coll. Vol. 2: 583
