The Gattermann–Koch reaction, named after the German chemists Ludwig Gattermann and Julius Arnold Koch, in organic chemistry refers to a Friedel–Crafts acylation reaction in which carbon monoxide and hydrochloric acid are used in situ with Friedel–Crafts catalyst, namely AlCl3 to produce a benzaldehyde derivative from a benzene derivative in one step. Benzaldehyde and many aromatic aldehydes are conveniently synthesized by this reaction. Presence of traces of copper(I) chloride are also needed along with zinc chloride.
- Gattermann, L.; Koch, J. A. (1897). "Eine Synthese aromatischer Aldehyde". Ber. 30: 1622. doi:10.1002/cber.18970300288.
- LI Jie Jack (2003). Name Reactions: A Collection of Detailed Reaction Mechanisms (available on Google Books) (2nd ed.). Springer. p. 157. ISBN 3-540-40203-9.
- G. H. Coleman, David Craig (1943), "p-Tolualdehyde", Org. Synth.; Coll. Vol. 2: 583