|Location||NE 2 and Main St., Hyannis, Nebraska|
|Area||less than one acre|
|Architectural style||Greek Revival, Second Empire|
|NRHP Reference #||76001132|
|Added to NRHP||October 29, 1976|
The Hotel DeFair, at NE 2 and Main St. in Hyannis, Nebraska, and also known as the Hyannis Hotel, was built in 1898 and is listed on the National Register of Historic Places (NRHP). According to its NRHP nomination, it once was considered to be the best hotel and restaurant in western Nebraska.
- "National Register Information System". National Register of Historic Places. National Park Service. 2010-07-09.
- Janet Jeffries (January 9, 1976). "National Register of Historic Places Inventory/Nomination: Hotel DeFair / Hyannis Hotel". National Park Service. and accompanying six photos from 1912 and 1974
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