His work has appeared in publications from all the major US and UK comics companies, from Fleetway Editions' Crisis, Dark Horse's Manga Mania, Deadline magazine to work for DC Comics' Vertigo imprint.
He is best known for his character Bic who appeared in a self-published series of comics (now collected as Skidmarks) and then as part of the larger cast of The End of The Century Club.
In 2008 he edited The Mammoth Book of Best New Manga, an anthology presenting the work of an international roster of contributors whose comics show the influence or inspiration of Japanese manga and anime, including: Michiru Morikawa, winner of the International Manga and Anime Festival's grand prize in 2005, previous category winners Asia Alfasi and Joanna Zhou, as well as established UK cartoonists Andi Watson and Craig Conlan. There have been three volumes of this series.
Ten episodes of his animated online comic strip Jean Genii (originally commissioned by the BBC) are viewable online.
Ed Hillyer's first novel, The Clay Dreaming, was published in March 2010 by Myriad Editions.
In 2013, he completed a new graphic novel "Room To Live" about a relationship between a middle-aged romance novelist and a teenage runaway. It was published by SelfMadeHero.
- The End of the Century Club: Countdown (Slab-O-Concrete, 1999, ISBN 0-9527386-0-0)
- Time Warp: The End of the Century Club (Slab-O-Concrete, 1999, ISBN 1-899866-20-5)
- Skidmarks (Active Images, 2004, ISBN 0-9740567-4-X)
- Ballast (with writer Joe Kelly, Active Images, 2005, ISBN 0-9766761-2-5)
- The Mammoth Book of Best New Manga Vol.1 (Carroll & Graf, 2006, ISBN 0-7867-1838-2)
- The Mammoth Book of Best New Manga Vol.2 (Constable & Robinson, 2007, ISBN 978-1-84529-642-1)
- The Mammoth Book of Best New Manga Vol.3 (Robinson Publishing, 2008, ISBN 978-1-84529-827-2)
- The Clay Dreaming (Myriad Editions, 2010, ISBN 978-0-9562515-0-3)
- Jean Genii
- An Active Images Three-Fer: Bal,last, Solstice, & Gunpowder Girl , Newsarama, September 7, 2005