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Insulitis is an inflammation of the islets of Langerhans of the pancreas.[1] Pancreatic β-cells become infiltrated by mononuclear cells, leading to inflammation. This lymphocyte infiltration can result in destruction of the insulin producing beta cells of the islets,[2] and clinical diabetes. Insulitis can be studied in the MLDS mouse model or the NOD mouse model of type-1 diabetes. The chemokine family of proteins may play a key role in promoting leukocytic infiltration into the pancreas.


  1. ^ "insulitis" at Dorland's Medical Dictionary
  2. ^ In't Veld P, Lievens D, De Grijse J et al. (September 2007). "Screening for insulitis in adult autoantibody-positive organ donors". Diabetes 56 (9): 2400–4. doi:10.2337/db07-0416. PMID 17563060.