Jeremy Pied made his Ligue 1 debut for Olympique Lyonnais on matchday 1 of the 2010/2011 season against Monaco, coming on from the bench in 76th minute for Bafétimbi Gomis. The match ended a goalless draw. He made a first Ligue 1 start in the game against Valenciennes in week 5 and scored a heading goal in 26th minute on Jimmy Briand's cross. However Gaetan Bong scored an equalizer in 69th minute and the match ended 1-1 with Jeremy Pied being named the man of the match by L'Equipe. On Tuesday, September 14, 2010, he played his first Champions League match against Schalke 04, entering shortly after the hour mark, replacing Michel Bastos the only scorer of the match for a 1-0 victory. Pied's promising performances have earned him the trust of Claude Puel and he started playing regularly starting matches or coming in from the bench. On October 2, 2010 he played the full match against Nancy and made an assist to the second goal of the match scored by Jimmy Briand. Lyon eventually won the game 3-2. On October 17, 2010, Jeremy Pied again made the starting lineup in a vital match against Lille. After all four goals of the game were scored, he quickly picked up two yellow cards which saw him expelled from the game, but Lyon held on and won the game 3-1. On November 14, 2010, he volleyed the only goal of the match, and his second goal of the season, against Nice after Yoann Gourcuff's cross. On December 3, 2010, Olympique Lyonnais announced contract extension for Jérémy for 2 years until June 2014. Pied scored his third goal for Lyon in 4-0 thumping of Nancy coming on from the bench in 69th minute and scoring a header in 76th from Michel Bastos' cross. He scored his first 2011/2012 Ligue 1 season goal on August 27, 2011 against Montpellier.