Journal of Clinical Investigation

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Journal of Clinical Investigation  
Abbreviated title (ISO 4)
J. Clin. Invest.
Discipline Biomedicine
Language English
Edited by Howard A. Rockman
Publication details
Publication history
Frequency Monthly; articles published weekly online
ISSN 0021-9738 (print)
1558-8238 (web)
LCCN 27010044
OCLC no. 01445593

The Journal of Clinical Investigation (JCI) is a peer-reviewed medical journal published by the American Society for Clinical Investigation (ASCI).

Evaluation and peer review of research[edit]

The JCI receives submissions from authors worldwide. Unlike at most commercial journals, an Editorial Board made up of scientists actively engaged in scientific discovery rigorously evaluates each submitted article for scientific merit to determine its suitability for the JCI. Submitted manuscripts are sent out for external peer review if the board member with specific expertise in the subject area handling the manuscript believes it represents a substantial conceptual advance and is appropriate for the broad readership of the JCI. The JCI strives for timely and thoughtful decisions on manuscripts that incorporate the recommendations from peer review and the discussion at the weekly Editorial Board meeting.


Research articles focus on the mechanisms of disease, with an emphasis on basic research, early-stage clinical studies in humans, and new research tools and techniques. The JCI also publishes scientific reviews in edited series or as stand-alone articles, commentaries on research articles, personal perspectives, editorials, and news and feature items. A companion to the journal, JCI Impact, launched in January 2013, summarizes and highlights the content of each month's issue.

Current Editorial Board[edit]

The Editorial Board comprises scientists associated with an academic medical center, which changes every five years, allowing for new editorial perspectives and areas of expertise. Since 2012, the journal has been headed by Editor in Chief Dr. Howard A. Rockman and an Editorial Board of peer scientists at Duke University Medical Center, the University of North Carolina, Duke-NUS, and the Sanford-Burnham Medical Research Institute.

Influential research[edit]

The top-cited JCI articles as of October 2014, according to Scopus

Title Year published No. of citations
Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria 1973 3,725
Obesity is associated with macrophage accumulation in adipose tissue 2003 3,538
The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum 1955 2,651
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance 2003 2,605
An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels 1990 2,593
Role of AMP-activated protein kinase in mechanism of metformin action 2001 2,127
Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance 1995 2,000
Safety and antitumor activity of recombinant soluble Apo2 ligand 1999 1,998
Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone 1996 1,763
Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques 1994 1,716
Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF 1998 1,686

Business model[edit]

The JCI is a nonprofit publication of the ASCI, with a publishing office in Ann Arbor, Michigan. All JCI research articles are freely available online upon publication. Revenue derives from submission fees, which support maintenance of an Editorial Board; page charges to authors for published articles; and subscription fees, which apply in the case of most non-research articles. The JCI deposits all articles in PubMed Central; however, most non-research articles are embargoed for release by PubMed Central until the start of the year after the year in which those articles are published.


The JCI was established by the ASCI in 1924 to serve as the major U.S. venue for research on disease and clinical medicine. A publication of the American Society for Clinical Investigation, the journal initially received financial backing from the Rockefeller Institute for Medical Research (now known as Rockefeller University). The journal then turned to a model based on individual and university clinic subscriptions. At a time of financial struggles during the Great Depression, the Chemical Foundation ran the JCI (1931–1940). Page charges were instituted in 1965 to offset publication costs. Rockefeller University Press published the journal from 1967 until 1999. Since that time, the ASCI has published the JCI. In 1996 the JCI became the first major scientific journal to make its content available barrier-free online;[1] Ajit Varki was the editor-in-chief at the time of the transition.

Several articles focus on the history of the journal:

Editors of the Journal of Clinical Investigation

Name Tenure Affiliation
G. Canby Robinson 1924–1927 Vanderbilt University
J. Harold Austin 1928–1934 University of Pennsylvania
Randolph West 1935–1940 Presbyterian Hospital (New York)
James L. Gamble 1941–1946 Harvard University
Eugene B. Ferris 1947–1951 Cincinnati General Hospital
Stanley E. Bradley 1952–1956 Columbia University
Philip K. Bondy 1957–1961 Yale University
Arnold S. Relman 1962–1966 Harvard University
Paul A. Marks 1967–1970 Columbia University
DeWitt S. Goodman 1971–1972 Columbia University
Jean D. Wilson 1972–1977 University of Texas Southwestern Medical Center
Philip W. Majerus 1977–1981 Washington University
Stuart Kornfeld 1981–1982 Washington University
Thomas P. Stossel 1982–1985 Harvard University
Joseph Avruch 1986–1987 Harvard University
Bruce F. Scharschmidt 1987–1992 University of California–San Francisco
Ajit P. Varki 1992–1996 University of California–San Diego
Paul A. Insel 1996–1997 University of California–San Diego
Martin F. Kagnoff 1996–1997 University of California–San Diego
Stephen J. Weiss 1997–2002 University of Michigan
Andrew R. Marks 2002 2007 Columbia University
Laurence A. Turka 2007–2012 University of Pennsylvania
Howard A. Rockman 2012–present Duke University


  1. ^ Howell JD. A history of the American Society for Clinical Investigation. J Clin Invest. 2009;119(4):694.

External links[edit]