Jamaica Ginger extract, known in the United States by the slang name "Jake," was a late 19th-century patent medicine that provided a convenient way to bypass Prohibition laws, since it contained between 70-80% ethanol by weight.
"Jake" was not itself dangerous, but the U.S. Treasury Department, which administered the Prohibition laws, recognized its potential as an illicit alcohol source, and because of this, it required changes in the solids content of Jake to discourage drinking. The minimum requirement of ginger solids per cubic centimeter of alcohol resulted in a fluid that was extremely bitter and difficult to drink. Occasionally, Department of Agriculture inspectors would test shipments of Jake by boiling the solution and weighing the remaining solid residue. In an effort to trick regulators, bootleggers replaced the ginger solids with a small amount of ginger and either castor oil or molasses.
A pair of amateur chemists and bootleggers, Harry Gross and Max Reisman, worked to develop an alternative adulterant that would pass the tests, but still be somewhat palatable. They sought advice from a professor at MIT who did not realize it was meant for internal consumption. They settled on a plasticizer, tri-o-tolyl phosphate (also known as tri-ortho cresyl phosphate, TOCP, or Tricresyl phosphate), that was able to pass the Treasury Department's tests but preserved Jake's drinkability. TOCP was originally thought to be non-toxic; however, it was later determined to be a neurotoxin that causes axonal damage to the nerve cells in the nervous system of human beings, especially those located in the spinal cord. The resulting type of paralysis is now referred to as organophosphate-induced delayed neuropathy, or OPIDN.
In 1930, large numbers of Jake users began to lose the use of their hands and feet. Some victims could walk, but they had no control over the muscles which would normally have enabled them to point their toes upward. Therefore, they would raise their feet high with the toes flopping downward, which would touch the pavement first followed by their heels. The toe first, heel second pattern made a distinctive “tap-click, tap-click" sound as they walked. This very peculiar gait became known as the jake walk and those afflicted were said to have jake leg, jake foot, or jake paralysis. Additionally, the calves of the legs would soften and hang down and the muscles between the thumbs and fingers would atrophy.
Within a few months, the TOCP-adulterated Jake was identified as the cause of the paralysis, and the contaminated Jake was recovered. But by that time, it was too late for many victims. Some users did recover full, or partial, use of their limbs. But for most, the loss was permanent. The total number of victims was never accurately determined, but is frequently quoted as between 30,000 and 50,000. Many victims were immigrants to the United States, and most were poor, with little political or social influence. The victims received very little assistance, aside from being the subject of a few blues songs recorded in the early 1930s (e.g. "Jake Walk Papa" by Asa Martin, "Jake Leg Blues" by the Mississippi Sheiks, "Alcohol and Jake Blues" by Tommy Johnson and "Jake Liquor Blues" by Ishman Bracey).
Although this incident became well-known, later cases of organophosphate poisoning occurred in Germany, Spain, Italy, and, on a large scale, in Morocco in 1959, where cooking oil adulterated with jet engine lubricant from an American airbase led to paralysis in approximately 10,000 victims, and caused an international incident.
- Jamaica ginger ("Ginger Jake") is a plot element in two episodes of The Untouchables, an American TV series.
- "Ginger Jake" also makes an appearance in the movie Quid Pro Quo, where "wannabes" (people who would like to be disabled) are helped by Ginger Jake to become disabled.
- In Sara Gruen's 2006 novel Water for Elephants jake paralysis afflicts one character, Camel, after drinking contaminated Jamaica Ginger.
- The Three Terrors—Stephin Merritt, LD Beghtol, and Dudley Klute—performed Jake Walk Papa at their 2003 extravaganza Intoxication at The Bowery Ballroom, New York.
- In the novel The Black Dahlia, the protagonist reveals early on that his mother went blind and fell to her death after drinking jake, leading to his resentment of his father for purchasing it.
- The character Eddie, played by Walter Brennan in Howard Hawks's To Have and Have Not, is a "rummy"--an alcoholic—whom Brennan endows with a peculiar gait that may be meant to suggest jake leg.
- Savannah, Georgia-based Baroness (band) recorded a song called "Jake Leg" for its album Blue Record.
- In the novel Hotel on the Corner of Bitter and Sweet the main character purchases Jamaica Ginger in order to gain access to a jazz club when he was a minor.
- Baum, Dan, "Jake Leg", The New Yorker September 15, 2003, p. 50-57. (PDF)
- Blum, Deborah. The Poisoner's Handbook: Murder and the Birth of Forensic Medicine in Jazz Age New York (Penguin Press, February 18, 2010)
- Burns, Eric. The Spirits of America: A Social History of Alcohol (Philadelphia: Temple University Press, 2003) pp. 221–223
- Kidd, J. G, and Langworthy, O. R. Jake paralysis. Paralysis following the ingestion of Jamaica ginger extract adulterated with triortho-chesyl phosphate. Bulletin of the Johns Hopkins Hospital, 1933, 52, 39.
- Gussow, Leon MD. The Jake Walk and Limber Trouble: A Toxicology Epidemic. Emergency Medicine News"". 26(10):48, October 2004. 
- Morgan, John P. and Tulloss, Thomas C. The Jake Walk Blues: A toxicological tragedy mirrored in popular music. JEMF (John Edward s Memorial Foundation) Quarterly, 1977, 122-126.
- Sara Gruen, (2006). Water for Elephants : A Novel. Chapel Hill, NC: Algonquin Books. ISBN 1-56512-499-5.
- U.S. Congress, Office of Technology Assessment, Neurotoxicity: Identifying and Controlling Poisons of the Nervous System, OTA-BA-436 (Washington, DC: U.S. Government Printing Office, April 1990).
- Kearney, Paul W. Our Food and Drug G-Men The Progressive July 10, 1944
- The Epidemiologic Side of Toxicology (slides 6 - 10 deal with the Jamaica Ginger Epidemic)
- Songs about jake leg.
- The Jake Leg Infamy. This film was originally shown September 2009, at the North American College of Clinical Toxicology meeting in San Antonio, TX. It was part of the Toxicology Historical Society component. It has a Standard YouTube License.