The James E. Simpson House is an historic house at 606 Prospect Street in Methuen, Massachusetts. It is a 2-1/2 story house, finished in wooden clapboards, with a steeply-pitched gable roof with exposed trusses. It was built c. 1920, and features typical Craftsman features, including dormers with deep eaves supported by trusses, and half-timbering above the windows. Its porch and foundation are faced in glazed fieldstones, as is its central chimney. The house is Methuen's finest example of the Craftsman/bungalow style.