Greenberg-Rohatyn was born in St Louis and is the daughter of author Jan Greenberg and Ronald K. Greenberg, the co-founder of art gallery Greenberg Van Doren in St Louis and New York. She graduated from Vassar College. As a young curator, following her stint at the New York University Institute of Fine Arts in the early nineties, she assisted then director Norman Rosenthal with American Art in the Twentieth Century: Painting and Sculpture. 1913-1933, a 1993 survey of American art from a European perspective at the Royal Academy of Arts in London and at Martin-Gropius-Bau in Berlin. She later became a partner of what was then the Artemis Greenberg Van Doren Gallery, a joint venture created in 2000 by Greenberg Van Doren and Artemis Fine Arts, a London gallery that specialized in old master and 19th-century paintings.
The double-width Rafael Viñoly–designed townhouse on the Upper East Side, where Greenberg-Rohatyn has lived since 2002 with her family also serves as her salon and gallery under the name Salon 94. Her personal collection includes pieces by David Hammons, Sarah Lucas, Julie Mehretu, Marilyn Minter, Richard Prince and Katy Grannan.
In 2006, Greenberg-Rohatyn coproduced The Music of Regret, the first film directed by Laurie Simmons and starring Meryl Streep. She later appeared in the 2011 reality competition show Work of Art: The Next Great Artist alongside Jerry Saltz and China Chow.
Greenberg-Rohatyn is the Board Chair of Performa, the non-profit responsible for the international performance art biennial and sits on the selection committee for the New York edition of Frieze Art Fair. She also serves on the National Board of Directors of the Contemporary Art Museum St. Louis. In 2014, she was named one of the top 25 most important women in the art world by Artnet.
- WEDDINGS; Jeanne Greenberg, Nicolas Rohatyn New York Times, September 14, 1997.
- Gallery - Greenberg Van Doren Gallery
- Diane Solway (October 2012), Gen W: Jeanne Greenberg Rohatyn W.
- Roberta Smith (January 17, 2003), A Bread-Crumb Trail to the Spirit of the Times New York Times.
- Carol Vogel (August 4, 2000), A London-U.S. Merger New York Times.
- Sandra Ballentine (April 7, 2010), Profiles in Style: Jeanne Greenberg-Rohatyn T: The New York Times Style Magazine.
- Guy Trebay (November 29, 2013), From Behind the Canvas New York Times.
- Performa 11 · Staff & Board
- About | Frieze Art Fair New York
- Board of Directors Contemporary Art Museum St. Louis.
- "25 Art World Women at the Top, From Sheikha Al-Mayassa to Yoko Ono". Artnet. Retrieved 18 April 2014.