KLK11

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Kallikrein-related peptidase 11
Identifiers
Symbols KLK11 ; PRSS20; TLSP
External IDs OMIM604434 MGI1929977 HomoloGene27048 ChEMBL: 3031 GeneCards: KLK11 Gene
RNA expression pattern
PBB GE KLK11 205470 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11012 56538
Ensembl ENSG00000167757 ENSMUSG00000067616
UniProt Q9UBX7 Q9QYN3
RefSeq (mRNA) NM_001136032 NM_001177373
RefSeq (protein) NP_001129504 NP_001170844
Location (UCSC) Chr 19:
51.53 – 51.53 Mb
Chr 7:
43.77 – 43.78 Mb
PubMed search [1] [2]

Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene.[1][2][3][4][5]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in two transcript variants encoding two different isoforms which are differentially expressed.[5]

References[edit]

  1. ^ Yoshida S, Taniguchi M, Suemoto T, Oka T, He X, Shiosaka S (Oct 1998). "cDNA cloning and expression of a novel serine protease, TLSP". Biochim Biophys Acta 1399 (2–3): 225–8. PMID 9765601. 
  2. ^ Yousef GM, Scorilas A, Diamandis EP (Apr 2000). "Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family". Genomics 63 (1): 88–96. doi:10.1006/geno.1999.6072. PMID 10662548. 
  3. ^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. 
  4. ^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. 
  5. ^ a b "Entrez Gene: KLK11 kallikrein-related peptidase 11". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: S01.257