LHX1

LIM homeobox 1
Identifiers
Symbols	LHX1; LIM-1; LIM1
External IDs	OMIM: 601999 MGI: 99783 HomoloGene: 4068 GeneCards: LHX1 Gene
Gene Ontology Molecular function • nucleic acid binding transcription factor activity • sequence-specific DNA binding transcription factor activity • transcription corepressor activity • zinc ion binding • sequence-specific DNA binding • metal ion binding Cellular component • intracellular • nucleus • protein complex Biological process • urogenital system development • metanephros development • ureteric bud development • gastrulation with mouth forming second • ectoderm formation • endoderm formation • neuron migration • kidney development • mesonephros development • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • cell-cell signaling • pattern specification process • nervous system development • motor axon guidance • anatomical structure morphogenesis • post-embryonic development • embryonic pattern specification • organ morphogenesis • anterior/posterior axis specification • anterior/posterior pattern specification • dorsal/ventral pattern formation • regulation of gene expression • retina layer formation • ventral spinal cord development • spinal cord association neuron differentiation • telencephalon development • cerebellum development • cerebellar Purkinje cell differentiation • forebrain regionalization • cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation • cell differentiation • somite rostral/caudal axis specification • metanephric ureteric bud development • oviduct epithelium development • uterine epithelium development • nephric duct elongation • horizontal cell localization • positive regulation of embryonic development • cellular response to fibroblast growth factor stimulus • negative regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • anatomical structure formation involved in morphogenesis • embryonic viscerocranium morphogenesis • pronephros development • retina development in camera-type eye • embryonic retina morphogenesis in camera-type eye • uterus development • oviduct development • cervix development • vagina development • head development • epithelium development • paramesonephric duct development • comma-shaped body morphogenesis • S-shaped body morphogenesis • renal vesicle morphogenesis • mesonephric duct development • nephric duct morphogenesis • metanephric glomerulus development • metanephric comma-shaped body morphogenesis • metanephric renal vesicle morphogenesis • metanephric S-shaped body morphogenesis • primitive streak formation • positive regulation of branching involved in ureteric bud morphogenesis • positive regulation of gastrulation • positive regulation of anterior head development • positive regulation of nephron tubule epithelial cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3975	16869
Ensembl	ENSG00000132130	ENSMUSG00000018698
UniProt	P48742	P63006
RefSeq (mRNA)	NM_005568.3	NM_008498.2
RefSeq (protein)	NP_005559.2	NP_032524.1
Location (UCSC)	Chr 17: 35.29 – 35.3 Mb	Chr 11: 84.33 – 84.34 Mb
PubMed search	[1]	[2]

LIM homeobox 1, also known as LHX1, is a gene.

This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in control of differentiation and development of neural and lymphoid cells. A similar protein in mice is an essential regulator of the vertebrate head organizer.

Further reading

• Shawlot W, Behringer RR (1995). "Requirement for Lim1 in head-organizer function.". Nature 374 (6521): 425–30. doi:10.1038/374425a0. PMID 7700351. 
• Bozzi F, Bertuzzi S, Strina D, et al. (1997). "The exon-intron structure of human LHX1 gene.". Biochem. Biophys. Res. Commun. 229 (2): 494–7. doi:10.1006/bbrc.1996.1832. PMID 8954926. 
• Dong WF, Heng HH, Lowsky R, et al. (1997). "Cloning, expression, and chromosomal localization to 11p12-13 of a human LIM/HOMEOBOX gene, hLim-1.". DNA Cell Biol. 16 (6): 671–8. PMID 9212161. 
• Jurata LW, Pfaff SL, Gill GN (1998). "The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors.". J. Biol. Chem. 273 (6): 3152–7. doi:10.1074/jbc.273.6.3152. PMID 9452425. 
• Ostendorff HP, Peirano RI, Peters MA, et al. (2002). "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors.". Nature 416 (6876): 99–103. doi:10.1038/416099a. PMID 11882901. 
• Phillips JC (2003). "Assignment of LHX1 to human chromosome bands 17q11.2→q12 by use of radiation hybrid mapping and somatic cell hybridization.". Cytogenet. Genome Res. 97 (1–2): 140D. doi:10.1159/000064048. PMID 12438757. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Zody MC, Garber M, Adams DJ, et al. (2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage". Nature 440 (7087): 1045–9. doi:10.1038/nature04689. PMC 2610434. PMID 16625196. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2610434.