|Pacinian corpuscle, with its system of capsules and central cavity.
a. Arterial twig, ending in capillaries, which form loops in some of the intercapsular spaces, and one penetrates to the central capsule.
b. The fibrous tissue of the stalk.
n. Nerve tube advancing to the central capsule, there losing its white matter and stretching along the axis to the opposite end, where it ends by a tuberculated enlargement.
|Lamellar capsule labeled at bottom|
|Gray's||subject #233 1060|
Lamellar corpuscles, or Pacinian corpuscles, are one of the four major types of mechanoreceptor. They are nerve endings in the skin responsible for sensitivity to vibration and pressure. Vibrational role may be used to detect surface, e.g., rough vs. smooth. Lamellar corpuscles are also found in the pancreas, where they detect vibration and possibly very low frequency sounds.
The Lamellar corpuscle is oval-shaped and approximately 1 mm in length. The entire corpuscle is wrapped by a layer of connective tissue. It has 20 to 60 concentric lamellae composed of fibrous connective tissue and fibroblasts, separated by gelatinous material. The lamellae are very thin, flat, modified Schwann cells. In the center of the corpuscle is the inner bulb, a fluid-filled cavity with a single afferent unmyelinated nerve ending.
Lamellar corpuscles detect gross pressure changes and vibrations and are rapidly adapting (phasic) receptors. Any deformation in the corpuscle causes action potentials to be generated by opening pressure-sensitive sodium ion channels in the axon membrane. This allows sodium ions to influx, creating a receptor potential.
These corpuscles are especially susceptible to vibrations, which they can sense even centimeters away. Their optimal sensitivity is 250 Hz, and this is the frequency range generated upon fingertips by textures made of features smaller than 200 µm. Lamellar corpuscles cause action potentials when the skin is rapidly indented but not when the pressure is steady, due to the layers of connective tissue that cover the nerve ending. It is thought that they respond to high-velocity changes in joint position.
How it works 
Lamellar corpuscles sense stimuli due to the deformation of their rings of lamellae, which press on the top of the sensory neuron and causes it to bend. When the lamellae are deformed, due to either pressure or release of pressure, a generator potential is created as it physically deforms the plasma membrane of the tip of the neuron, making it "leak" Na+ ions. If this potential reaches a certain threshold, nerve impulses or action potentials are formed by pressure-sensitive sodium channels at the first node of Ranvier, the first node of the myelinated sensory neuron. This impulse is now transferred along the axon with the use of sodium channels and sodium/potassium pumps in the axon membrane.
Once the top of the neuron is depolarized, it will depolarize the first node of Ranvier; however, as it is a rapidly adapting fibre, this does not carry on indefinitely, and the signal propagation ceases. This is a graded response, meaning that the greater the deformation, the greater the generator potential. This information is encoded in the frequency of impulses, since a bigger or faster deformation induces a higher impulse frequency. Action potentials are formed when the skin is rapidly distorted but not when pressure is continuous. The frequencies of the impulses decrease quickly and soon stop due to the layers of connective tissue that cover the nerve ending. This adaptation is useful, as it stops the nervous system from being overloaded with unnecessary information such as the pressure exerted by clothing.
Additional images 
See also 
- Thomas Caceci. "Example: Lamellar Corpuscle". VM8054 Veterinary Histology. Retrieved 2013-05-19.
- Kandel, Edited by Eric R.; Schwartz, James H.; Jessell, Thomas M. (2000). Principles of neural science. New York: McGraw-Hill, Health Professions Division. ISBN 0-8385-7701-6
- Scheibert J, Leurent S, Prevost A, Debrégeas G. (2009). The role of fingerprints in the coding of tactile information probed with a biomimetic sensor. Science. 323(5920):1503-6. PMID 19179493 doi:10.1126/science.1166467
- Biological Psychology.
- (synd/2423 at Who Named It?)
- Virginia Commonwealth University
- Anatomy Atlases - Microscopic Anatomy, plate 06.124
- lamellated+corpuscles at eMedicine Dictionary
- Medical Illustration