In 2001, 16 acts achieved their first number-one single in Australia, either as a lead artist or featured guest, including Shaggy, Mýa, LeAnn Rimes, Pink, Lifehouse, Scandal'us and Alien Ant Farm. Shaggy, Rayvon, Scandal'us and Kylie Minogue were the only acts to have earned a number-one debut single this year. Reggae singer Shaggy, R&B singer Mýa and pop rock singer P!nk had two number-one singles that reached the top-spot. During the year, five collaboration singles reached the number-one position.
Shaggy's "Angel" and Alien Ant Farm's "Smooth Criminal" are the longest-running number-one singles of 2001, remaining in that position for eight weeks. It is followed by LeAnn Rimes' "Can't Fight the Moonlight", whose streak on the top spot reached six weeks. Another single with an extended chart run is Lifehouse's "Hanging by a Moment", which topped the chart for five weeks.
Lifehouse gained their first number-one single in Australia with their debut single "Hanging by a Moment", which stayed at the top spot for five consecutive weeks.
Mýa reached the top spot with two singles, as the lead artist on "Case of the Ex", which topped the chart for two weeks and as one of four acts on "Lady Marmalade", which stayed at the top spot for three consecutive weeks.