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Mediator complex subunit 6
Symbols MED6 ; NY-REN-28
External IDs OMIM602984 MGI1917042 HomoloGene3990 GeneCards: MED6 Gene
RNA expression pattern
PBB GE MED6 207079 s at tn.png
PBB GE MED6 210104 at tn.png
More reference expression data
Species Human Mouse
Entrez 10001 69792
Ensembl ENSG00000133997 ENSMUSG00000002679
UniProt O75586 Q921D4
RefSeq (mRNA) NM_005466 NM_027213
RefSeq (protein) NP_005457 NP_081489
Location (UCSC) Chr 14:
71.05 – 71.07 Mb
Chr 12:
81.57 – 81.6 Mb
PubMed search [1] [2]
Symbol Med6
Pfam PF04934
InterPro IPR007018

Mediator of RNA polymerase II transcription subunit 6 is one of the subunits of the Mediator complex. It is an enzyme that in humans is encoded by the MED6 gene.[1][2][3]


MED6 has been shown to interact with Thyroid hormone receptor alpha,[4] Estrogen receptor alpha,[5] MED21[6] and Cyclin-dependent kinase 8.[7][8][4][5][citation clutter]

Protein family details[edit]

This family of proteins represent the transcriptional mediator protein subunit 6 that is required for activation of many RNA polymerase II promoters and which are conserved from yeast to humans.[1]


  1. ^ a b Lee YC, Min S, Gim BS, Kim YJ (Aug 1997). "A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans". Mol Cell Biol 17 (8): 4622–32. PMC 232315. PMID 9234719. 
  2. ^ Jiang YW, Veschambre P, Erdjument-Bromage H, Tempst P, Conaway JW, Conaway RC, Kornberg RD (Aug 1998). "Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways". Proc Natl Acad Sci U S A 95 (15): 8538–8543. doi:10.1073/pnas.95.15.8538. PMC 21111. PMID 9671713. 
  3. ^ "Entrez Gene: MED6 mediator of RNA polymerase II transcription, subunit 6 homolog (S. cerevisiae)". 
  4. ^ a b Ito, M; Yuan C X, Malik S, Gu W, Fondell J D, Yamamura S, Fu Z Y, Zhang X, Qin J, Roeder R G (Mar 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell (UNITED STATES) 3 (3): 361–370. doi:10.1016/S1097-2765(00)80463-3. ISSN 1097-2765. PMID 10198638. 
  5. ^ a b Kang, Yun Kyoung; Guermah Mohamed, Yuan Chao-Xing, Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (5): 2642–2647. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMC 122401. PMID 11867769. 
  6. ^ Sun, X; Zhang Y, Cho H, Rickert P, Lees E, Lane W, Reinberg D (Aug 1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription". Mol. Cell (UNITED STATES) 2 (2): 213–222. doi:10.1016/S1097-2765(00)80131-8. ISSN 1097-2765. PMID 9734358. 
  7. ^ Yang, Fajun; DeBeaumont Rosalie, Zhou Sharleen, Näär Anders M (Feb 2004). "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator". Proc. Natl. Acad. Sci. U.S.A. (United States) 101 (8): 2339–2344. doi:10.1073/pnas.0308676100. ISSN 0027-8424. PMC 356952. PMID 14983011. 
  8. ^ Wang, G; Cantin G T, Stevens J L, Berk A J (Jul 2001). "Characterization of mediator complexes from HeLa cell nuclear extract". Mol. Cell. Biol. (United States) 21 (14): 4604–4613. doi:10.1128/MCB.21.14.4604-4613.2001. ISSN 0270-7306. PMC 87123. PMID 11416138. 

Further reading[edit]

External links[edit]

This article incorporates text from the public domain Pfam and InterPro IPR007018