MED6

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Mediator complex subunit 6
Identifiers
Symbols MED6 ; ARC33; NY-REN-28
External IDs OMIM602984 MGI1917042 HomoloGene3990 GeneCards: MED6 Gene
RNA expression pattern
PBB GE MED6 207079 s at tn.png
PBB GE MED6 210104 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10001 69792
Ensembl ENSG00000133997 ENSMUSG00000002679
UniProt O75586 Q921D4
RefSeq (mRNA) NM_001284209 NM_027213
RefSeq (protein) NP_001271138 NP_081489
Location (UCSC) Chr 14:
71.05 – 71.07 Mb
Chr 12:
81.57 – 81.6 Mb
PubMed search [1] [2]
Med6
Identifiers
Symbol Med6
Pfam PF04934
InterPro IPR007018

Mediator of RNA polymerase II transcription subunit 6 is one of the subunits of the Mediator complex. It is an enzyme that in humans is encoded by the MED6 gene.[1][2][3]

Protein family[edit]

This family of proteins represent the transcriptional mediator protein subunit 6 that is required for activation of many RNA polymerase II promoters and which are conserved from yeast to humans.[1]

Interactions[edit]

MED6 has been shown to interact with:

References[edit]

  1. ^ a b Lee Y, Min S, Gim B, Kim Y (Aug 1997). "A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans". Mol Cell Biol 17 (8): 4622–32. PMC 232315. PMID 9234719. 
  2. ^ Jiang Y, Veschambre P, Erdjument-Bromage H, Tempst P, Conaway J, Conaway R et al. (Aug 1998). "Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways". Proc Natl Acad Sci U S A 95 (15): 8538–8543. doi:10.1073/pnas.95.15.8538. PMC 21111. PMID 9671713. 
  3. ^ "Entrez Gene: MED6 mediator of RNA polymerase II transcription, subunit 6 homolog (S. cerevisiae)". 
  4. ^ Yang F, DeBeaumont R, Zhou S, Näär A (Feb 2004). "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2339–44. PMC 356952. PMID 14983011. 
  5. ^ Wang G, Cantin G, Stevens J, Berk A (Jul 2001). "Characterization of mediator complexes from HeLa cell nuclear extract". Mol. Cell. Biol. 21 (14): 4604–13. doi:10.1128/MCB.21.14.4604-4613.2001. PMC 87123. PMID 11416138. 
  6. ^ a b Ito M, Yuan C, Malik S, Gu W, Fondell J, Yamamura S et al. (Mar 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell 3 (3): 361–70. PMID 10198638. 
  7. ^ a b Kang Y, Guermah M, Yuan C, Roeder R (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2642–7. doi:10.1073/pnas.261715899. PMC 122401. PMID 11867769. 
  8. ^ Sun X, Zhang Y, Cho H, Rickert P, Lees E, Lane W et al. (Aug 1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription". Mol. Cell 2 (2): 213–22. PMID 9734358. 

Further reading[edit]

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Sun X, Zhang Y, Cho H, Rickert P, Lees E, Lane W et al. (1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription". Mol. Cell 2 (2): 213–222. doi:10.1016/S1097-2765(00)80131-8. PMID 9734358. 
  • Gu W, Malik S, Ito M, Yuan C, Fondell J, Zhang X et al. (1999). "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation". Mol. Cell 3 (1): 97–108. doi:10.1016/S1097-2765(00)80178-1. PMID 10024883. 
  • Ito M, Yuan C, Malik S, Gu W, Fondell J, Yamamura S et al. (1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell 3 (3): 361–370. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638. 
  • Rachez C, Lemon B, Suldan Z, Bromleigh V, Gamble M, Näär A et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature 398 (6730): 824–828. doi:10.1038/19783. PMID 10235266. 
  • Näär A, Beaurang P, Zhou S, Abraham S, Solomon W, Tjian R (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature 398 (6730): 828–832. doi:10.1038/19789. PMID 10235267. 
  • Scanlan M, Gordan J, Williamson B, Stockert E, Bander N, Jongeneel V et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer 83 (4): 456–464. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479. 
  • Ge K, Guermah M, Yuan C, Ito M, Wallberg A, Spiegelman B et al. (2002). "Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis". Nature 417 (6888): 563–567. doi:10.1038/417563a. PMID 12037571. 
  • Kato Y, Habas R, Katsuyama Y, Näär A, He X (2002). "A component of the ARC/Mediator complex required for TGF beta/Nodal signalling". Nature 418 (6898): 641–646. doi:10.1038/nature00969. PMID 12167862. 
  • Sato S, Tomomori-Sato C, Banks C, Sorokina I, Parmely T, Kong S et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". J. Biol. Chem. 278 (17): 15123–15127. doi:10.1074/jbc.C300054200. PMID 12584197. 
  • Sato S, Tomomori-Sato C, Banks C, Parmely T, Sorokina I, Brower C et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem. 278 (50): 49671–49674. doi:10.1074/jbc.C300444200. PMID 14576168. 
  • Tomomori-Sato C, Sato S, Parmely T, Banks C, Sorokina I, Florens L et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–5851. doi:10.1074/jbc.M312523200. PMID 14638676. 
  • Yang F, DeBeaumont R, Zhou S, Näär A (2004). "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2339–2344. doi:10.1073/pnas.0308676100. PMC 356952. PMID 14983011. 
  • Sato S, Tomomori-Sato C, Parmely T, Florens L, Zybailov B, Swanson S et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Mol. Cell 14 (5): 685–691. doi:10.1016/j.molcel.2004.05.006. PMID 15175163. 
  • Pavri R, Lewis B, Kim T, Dilworth F, Erdjument-Bromage H, Tempst P et al. (2005). "PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator". Mol. Cell 18 (1): 83–96. doi:10.1016/j.molcel.2005.02.034. PMID 15808511. 

External links[edit]

This article incorporates text from the public domain Pfam and InterPro IPR007018