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Meprin A, alpha (PABA peptide hydrolase)
Symbols MEP1A ; PPHA
External IDs OMIM600388 MGI96963 HomoloGene31323 GeneCards: MEP1A Gene
EC number
RNA expression pattern
PBB GE MEP1A 206000 at tn.png
More reference expression data
Species Human Mouse
Entrez 4224 17287
Ensembl ENSG00000112818 ENSMUSG00000023914
UniProt Q16819 P28825
RefSeq (mRNA) NM_005588 NM_008585
RefSeq (protein) NP_005579 NP_032611
Location (UCSC) Chr 6:
46.76 – 46.81 Mb
Chr 17:
43.47 – 43.5 Mb
PubMed search [1] [2]

Meprin A subunit alpha also known as endopeptidase-2 or PABA peptide hydrolase is the alpha subunit of the meprin A enzyme that in humans is encoded by the MEP1A gene.[1][2] The MEP1A locus is on chromosome 6p in humans and on chromosome 17 in mice.[3]


The meprin alpha subunit product of the MEP1A gene is processed in the endoplasmic reticulum during intracellular transport, and is secreted as homomeric meprin A. Meprin alpha subunits may self-associate, and once secreted, form very large multimers, with a molecular mass of over 1 million daltons. In cells concurrently expressing MEP1B, the meprin alpha and meprin beta subunits form disulfide dimers that interact to form membrane bound heterotetrameric meprin A .


  1. ^ Bond JS, Rojas K, Overhauser J, Zoghbi HY, Jiang W (Jul 1995). "The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively". Genomics 25 (1): 300–3. doi:10.1016/0888-7543(95)80142-9. PMID 7774936. 
  2. ^ "Entrez Gene: MEP1A meprin A, alpha (PABA peptide hydrolase)". 
  3. ^ Banerjee S, Oneda B, Yap LM, Jewell DP, Matters GL, Fitzpatrick LR, Seibold F, Sterchi EE, Ahmad T, Lottaz D, Bond JS (May 2009). "MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease". Mucosal Immunol 2 (3): 220–31. doi:10.1038/mi.2009.3. PMC 2670347. PMID 19262505. 

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