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MPX may refer to:
- MPX filter, a function found in cassette decks
- Multiplexing, the process of combining multiple analog or digital signals into one
- Multi-Pointer X, an extension to X.Org
- MPX Microsoft Project Exchange File Format, a Microsoft Project file format
- Intel MPX, a set of Memory Protection Extensions to the x86 instruction set architecture
- .mpx, a video file format in the Kingston K-PEX 100
- IBM 1800 MPX, in the list of operating systems
- MPX bus, a PowerPC CPU bus, for example in the PowerPC G4
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