|Jmol-3D images||Image 1|
|Molar mass||198.18 g mol−1|
291 °C, 564 K, 556 °F
| (what is: / ?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Mimosine or leucenol is an alkaloid, β-3-hydroxy-4 pyridone amino acid. It is a toxic non-protein free amino acid otherwise chemically similar to tyrosine, and was first isolated from Mimosa pudica. It occurs in a few other Mimosa spp. and all members of the closely related genus Leucaena.
Mimosine melts with decomposition. The hydrochloride salt melts at 174.5–175.0 °C with decomposition; the hydrobromide decomposes at 179.5 °C, and the hydroiodide decomposes at 183.0–183.5 °C. Mimosine only forms monobasic acids, but the methyl ester forms a dihydrochloride, C7H9O2N2(COOMe)•2 HCl•½ H2O, mp. 175–6 °C.
Biological effects 
Although toxicosis has occurred in Australia, Papua New Guinea, Africa and Florida, it has not been recorded in any other tropical and subtropical regions. Goats in Burma lost hair when fed to diet containing 50% of Leucaena. Goats and cattle in Hawaii are able to degrade the 3,4-DHP ruminally. Tolerance might be related to the presence or absence of microbes tolerant to mimosine and 3,4-DHP. It is known that at least Australian goats do not share the abilities of their Hawaiian counterparts.
Bickel and Wibaut found in feeding experiments with rats and mice that leucenol is probably the toxic constituent of Leucaena glauca seeds, but they did not observe with these animals the loss of hair which seems to occur when these seeds are fed to cattle. Aung from Myanmar isolated the new subspecies of K. pneumonae that can degrade mimosine.
- Mascré, Compt. rend., 1937, 204, 890.
- Adams, Roger; Cristol, Stanley J.; Anderson, Arthur A.; Albert, Alfred A. (1945). J. Am. Chem. Soc. 67: 89. doi:10.1021/ja01217a032.
- T. Krude Exp. Cell Res. Volume 247, Issue 1, 1999, Pages 148-159
- Rec. Trav. Chim., 1946, 65, 65; Wibaut, Helv. Chim. Acta, 1946, 29, 1669; (with Kleipol), Rec. Trav. Chim., 1947, 66, 24, 459.
- Mascré and Ottenwälder, Bull. Sci. Pharmacol., 1941, 3, 3, 65.