Mitotic catastrophe is an event in which a cell is destroyed during mitosis. This is believed by some to occur as a result of an attempt at aberrant chromosome segregation early in mitosis, or as a result of DNA damage later.
The term ‘mitotic catastrophe’ is used to explain a mechanism of a delayed mitotic-linked cell death, a sequence of events that results from premature or inappropriate entry of cells into mitosis that can be caused by chemical or physical stresses. It can be triggered with agents influencing the stability of microtubule, various anticancer drugs and mitotic failure caused by defective cell cycle checkpoints. Mitotic catastrophe is the main form of cell death induced by ionizing radiation
Cells which fail to go through a mitotic catastrophe after a mitotic failure are likely to create aneuploid cells when they later reproduce, posing a risk of oncogenesis, potentially leading to cancer.
- Castedo M, Perfettini JL, Roumier T, Andreau K, Medema R, Kroemer G. (12 April 2004). "Cell death by mitotic catastrophe: a molecular definition". Oncogene 23 (16): 2825–2837. doi:10.1038/sj.onc.1207528. ISSN 0950-9232. PMID 15077146.
Vakifahmetoglu H, Olsson M, Zhivotovsky B. Death through a tragedy: mitotic catastrophe. Cell Death Differ 2008; 15: 1153–1162. url = http://www.apo-sys.eu/aposys/Publications/Publications2008-pdf/Vakifahmetoglu-tragedy.pdf