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Neuroligin 1
Symbols NLGN1 ; NL1
External IDs OMIM600568 MGI2179435 HomoloGene56690 GeneCards: NLGN1 Gene
RNA expression pattern
PBB GE NLGN1 205893 at tn.png
More reference expression data
Species Human Mouse
Entrez 22871 192167
Ensembl ENSG00000169760 ENSMUSG00000063887
UniProt Q8N2Q7 Q99K10
RefSeq (mRNA) NM_014932 NM_001163387
RefSeq (protein) NP_055747 NP_001156859
Location (UCSC) Chr 3:
173.11 – 174 Mb
Chr 3:
25.43 – 26.13 Mb
PubMed search [1] [2]

Neuroligin-1 is a protein that in humans is encoded by the NLGN1 gene.[1][2][3]

This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligin-1 acts as splice site-specific ligand for β-neurexins and has been shown to localize to the postsynaptic compartment at excitatory synapses and is involved in the formation and remodeling of central nervous system synapses.[3][4]


NLGN1 has been shown to interact with NRXN1[5][6] and DLG4.[7]

See also[edit]


  1. ^ Philibert RA, Winfield SL, Sandhu HK, Martin BM, Ginns EI (April 2000). "The structure and expression of the human neuroligin-3 gene". Gene 246 (1–2): 303–10. doi:10.1016/S0378-1119(00)00049-4. PMID 10767552. 
  2. ^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (April 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331. 
  3. ^ a b "Entrez Gene: NLGN1 neuroligin 1". 
  4. ^ Scheiffele P, Fan J, Choih J, Fetter R, Serafini T (June 2000). "Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons". Cell 101 (6): 657–69. doi:10.1016/S0092-8674(00)80877-6. PMID 10892652. 
  5. ^ Comoletti D, Flynn R, Jennings LL, et al. (December 2003). "Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta". The Journal of Biological Chemistry 278 (50): 50497–505. doi:10.1074/jbc.M306803200. PMID 14522992. 
  6. ^ Ichtchenko K, Nguyen T, Südhof TC (February 1996). "Structures, alternative splicing, and neurexin binding of multiple neuroligins". The Journal of Biological Chemistry 271 (5): 2676–82. doi:10.1074/jbc.271.5.2676. PMID 8576240. 
  7. ^ Irie M, Hata Y, Takeuchi M, et al. (September 1997). "Binding of neuroligins to PSD-95". Science 277 (5331): 1511–5. doi:10.1126/science.277.5331.1511. PMID 9278515. 

Further reading[edit]