The ground has hosted Gaelic games since the 1930s when CLG Naomh Adhamhnáin bought the land for £300. The ground opened on Sunday 2 May 1937, with the Bishop of Raphoe's blessing of the park, a hurling match between Donegal and Antrim, an address from GAA President Bob O'Keeffe and a football match between Donegal and Armagh.
During the Fleadh Cheoil na hÉireann 2006, the ground was used as a makeshift campsite for visitors to the town for the duration of the festival. On 11 November 2008, CLG Naomh Adhamhnáin confirmed that it had completed the purchase of 14.5 acres (59,000 m2) of land adjoining O'Donnell Park, which it intended to develop over the coming years into additional pitches for the club.
The Sam Maguire Cup and members of Donegal's 2012 All-Ireland winning team attended a world record attempt at O'Donnell Park on 29 September 2012.
On 25 March 2007, O'Donnell Park hosted its first inter-county football match in three decades when Donegal beat Kerry by 1-15 to 0-13 in the Allianz Football League. There was a half-hour delay after the Kerry team were unable to arrive on time due to fog at the airport. The match was broadcast live on TG4.
On 13 April 2008, the ground hosted its second inter-county football match. Derry beat Donegal 0-15 to 0-10 in the NFL Division 1 semi-final.