OLR1

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Oxidized low density lipoprotein (lectin-like) receptor 1
Protein OLR1 PDB 1ypo.png
PDB rendering based on 1ypo.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols OLR1 ; CLEC8A; LOX1; LOXIN; SCARE1; SLOX1
External IDs OMIM602601 MGI1261434 HomoloGene1910 GeneCards: OLR1 Gene
RNA expression pattern
PBB GE OLR1 210004 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4973 108078
Ensembl ENSG00000173391 ENSMUSG00000030162
UniProt P78380 Q9EQ09
RefSeq (mRNA) NM_001172632 NM_138648
RefSeq (protein) NP_001166103 NP_619589
Location (UCSC) Chr 12:
10.31 – 10.32 Mb
Chr 6:
129.49 – 129.51 Mb
PubMed search [1] [2]

Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) also known as lectin-type oxidized LDL receptor 1 (LOX-1) is a protein that in humans is encoded by the OLR1 gene.[1][2]

Function[edit]

LOX-1 is a receptor protein which belongs to the C-type lectin superfamily. Its gene is regulated through the cyclic AMP signaling pathway. The protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor.[2]

Clinical significance[edit]

Mutations of the OLR1 gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease.[2] Berberine inhibits ORL1 (LOX-1)with the improvement in hemoglobin A1c and AGEs in diabetics. Berberine hence protects against endothelial injury and enhances the endothelium-dependent vasodilatation, which is mediated in part through activation of the AMPK signaling cascade.[3]

References[edit]

  1. ^ Li X, Bouzyk MM, Wang X (Nov 1998). "Assignment of the human oxidized low-density lipoprotein receptor gene (OLR1) to chromosome 12p13.1→p12.3, and identification of a polymorphic CA-repeat marker in the OLR1 gene". Cytogenet Cell Genet 82 (1–2): 34–6. doi:10.1159/000015059. PMID 9763655. 
  2. ^ a b c "Entrez Gene: OLR1 oxidized low density lipoprotein (lectin-like) receptor 1". 
  3. ^ Wang Y, Huang Y, Lam KS, Li Y, Wong WT, Ye H, Lau CW, Vanhoutte PM, Xu A (June 2009). "Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase". Cardiovasc. Res. 82 (3): 484–92. doi:10.1093/cvr/cvp078. PMID 19251722. 

Further reading[edit]