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Oxidized low density lipoprotein (lectin-like) receptor 1
Protein OLR1 PDB 1ypo.png
PDB rendering based on 1ypo.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM602601 MGI1261434 HomoloGene1910 GeneCards: OLR1 Gene
RNA expression pattern
PBB GE OLR1 210004 at tn.png
More reference expression data
Species Human Mouse
Entrez 4973 108078
Ensembl ENSG00000173391 ENSMUSG00000030162
UniProt P78380 Q9EQ09
RefSeq (mRNA) NM_001172632 NM_001301094
RefSeq (protein) NP_001166103 NP_001288023
Location (UCSC) Chr 12:
10.31 – 10.32 Mb
Chr 6:
129.49 – 129.51 Mb
PubMed search [1] [2]

Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) also known as lectin-type oxidized LDL receptor 1 (LOX-1) is a protein that in humans is encoded by the OLR1 gene.[1][2]


LOX-1 is a receptor protein which belongs to the C-type lectin superfamily. Its gene is regulated through the cyclic AMP signaling pathway. The protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor.[2]

Clinical significance[edit]

Mutations of the OLR1 gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease.[2] Berberine inhibits ORL1 (LOX-1)with the improvement in hemoglobin A1c and AGEs in diabetics. Berberine hence protects against endothelial injury and enhances the endothelium-dependent vasodilatation, which is mediated in part through activation of the AMPK signaling cascade.[3]


  1. ^ Li X, Bouzyk MM, Wang X (Nov 1998). "Assignment of the human oxidized low-density lipoprotein receptor gene (OLR1) to chromosome 12p13.1→p12.3, and identification of a polymorphic CA-repeat marker in the OLR1 gene". Cytogenet Cell Genet 82 (1–2): 34–6. doi:10.1159/000015059. PMID 9763655. 
  2. ^ a b c "Entrez Gene: OLR1 oxidized low density lipoprotein (lectin-like) receptor 1". 
  3. ^ Wang Y, Huang Y, Lam KS, Li Y, Wong WT, Ye H, Lau CW, Vanhoutte PM, Xu A (June 2009). "Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase". Cardiovasc. Res. 82 (3): 484–92. doi:10.1093/cvr/cvp078. PMID 19251722. 

Further reading[edit]