C-type lectin

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Lectin C-type domain
PDB 1jzn EBI.jpg
Pentameric structure of rattlesnake venom lectin which is a galactose binding lectin.[1]
Identifiers
Symbol Lectin_C
Pfam PF00059
InterPro IPR001304
SMART CLECT
PROSITE PS50041
SCOP 2msb
SUPERFAMILY 2msb

A C-type lectin (CLEC) is a type of carbohydrate-binding protein domain known as a lectin.[2] The C-type designation is from their requirement for calcium for binding.[3] Proteins that contain C-type lectin domains have a diverse range of functions including cell-cell adhesion, immune response to pathogens and apoptosis.[4][5]

Classification[edit]

Drickamer et al. classified C-type lectins into 7 subgroups (I to VII) based on the order of the various protein domains in each protein.[6] This classification was subsequently updated in 2002, leading to seven additional groups (VIII to XIV).[7] Most recently, three further subgroups were added (XV to XVII).[2]

Group Name Associated domains
I Lecticans EGF, Sushi, Ig and Link domains
II Asialoglycoprotein and DC receptors None
III Collectins None
IV Selectins Sushi and EGF domains
V NK - cell receptors None
VI Multi-CTLD endocytic receptors FnII and Ricin domains
VII Reg group None
VIII Chondrolectin, Layilin None
IX Tetranectin None
X Polycystin WSC, REJ, PKD domains
XI Attractin (ATRN) PSI, EGF and CUB domains
XII Eosinophil major basic protein (EMBP) None
XIII DGCR2 None
XIV Thrombomodulin EGF domains
XV Bimlec None
XVI SEEC SCP and EGF domains
XVII CBCP/Frem1/QBRICK CSPG repeats and CalX-beta domains

CLECs include:

The "NK Cell lectin-like receptors" are a very closely related group:[8]

Additional proteins containing this domain include:

References[edit]

  1. ^ Walker JR, Nagar B, Young NM, Hirama T, Rini JM (April 2004). "X-ray crystal structure of a galactose-specific C-type lectin possessing a novel decameric quaternary structure". Biochemistry 43 (13): 3783–92. doi:10.1021/bi035871a. PMID 15049685. 
  2. ^ a b Zelensky AN, Gready JE (December 2005). "The C-type lectin-like domain superfamily". FEBS J. 272 (24): 6179–217. doi:10.1111/j.1742-4658.2005.05031.x. PMID 16336259. 
  3. ^ C-Type Lectin at the US National Library of Medicine Medical Subject Headings (MeSH)
  4. ^ Drickamer K (October 1999). "C-type lectin-like domains". Curr. Opin. Struct. Biol. 9 (5): 585–90. doi:10.1016/S0959-440X(99)00009-3. PMID 10508765. 
  5. ^ Cambi A, Figdor C (May 2009). "Necrosis: C-type lectins sense cell death". Curr. Biol. 19 (9): R375–8. doi:10.1016/j.cub.2009.03.032. PMID 19439262. 
  6. ^ Drickamer K (1993). "Evolution of Ca(2+)-dependent animal lectins". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology 45: 207–32. doi:10.1016/S0079-6603(08)60870-3. ISBN 978-0-12-540045-9. PMID 8341801. 
  7. ^ Drickamer K, Fadden AJ (2002). "Genomic analysis of C-type lectins". Biochem. Soc. Symp. (69): 59–72. PMID 12655774. 
  8. ^ NK Cell Lectin-Like Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

External links[edit]