Oshikuku is a Town in Omusati Region in the north of Namibia. It is the district capital of Oshikuku Constituency.
Oshikuku features a secondary school, Nuuyoma Senior Secondary School, and a hospital. After Iipumpu Ya Tshilongo, king of the Uukwambi from 1907 to 1932, had resisted the establishment of mission stations in his territory for years, he finally allowed the Catholic Church to establish the first mission station in former Ovamboland in Oshikuku in 1924. The station was established under the leadership of missionary and later Archbishop Joseph Gotthardt. Oshikuku is until today home to a Roman Catholic Church parish. Its neighbouring villages are Outapi, Elim and Ogongo.
Oshikuku is the birthplace of Liborius Ndumbukuti Nashenda, Cardinal of the Roman Catholic Church in Namibia. Iipumpu Ya Tshilongo, eighteenth king of the Uukwambi, died here in 1959.