Poly [ADP-ribose] polymerase 4 is an enzyme that in humans is encoded by the PARP4gene.
This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.
Jean L, Risler JL, Nagase T, et al. (1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett.446 (1): 6–8. doi:10.1016/S0014-5793(99)00173-8. PMID10100603.
Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res.3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID8724849.
van Zon A, Mossink MH, Schoester M, et al. (2001). "Multiple human vault RNAs. Expression and association with the vault complex.". J. Biol. Chem.276 (40): 37715–21. doi:10.1074/jbc.M106055200. PMID11479319.
van Zon A, Mossink MH, Schoester M, et al. (2002). "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly.". Biochem. Biophys. Res. Commun.291 (3): 535–41. doi:10.1006/bbrc.2002.6472. PMID11855821.
Mazzon E, Dugo L, Li JH, et al. (2002). "GPI 6150, a PARP inhibitor, reduces the colon injury caused by dinitrobenzene sulfonic acid in the rat.". Biochem. Pharmacol.64 (2): 327–37. doi:10.1016/S0006-2952(02)01075-4. PMID12123754.
Liu TJ, Lin SY, Chau YP (2002). "Inhibition of poly(ADP-ribose) polymerase activation attenuates beta-lapachone-induced necrotic cell death in human osteosarcoma cells.". Toxicol. Appl. Pharmacol.182 (2): 116–25. doi:10.1006/taap.2002.9438. PMID12140175.
Nie Z, Phenix BN, Lum JJ, et al. (2003). "HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation.". Cell Death Differ.9 (11): 1172–84. doi:10.1038/sj.cdd.4401094. PMID12404116.