PARP4

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Poly (ADP-ribose) polymerase family, member 4
Identifiers
Symbols PARP4 ; ADPRTL1; ARTD4; PARP-4; PARPL; PH5P; VAULT3; VPARP; VWA5C; p193
External IDs OMIM607519 MGI2685589 HomoloGene124423 ChEMBL: 6142 GeneCards: PARP4 Gene
EC number 2.4.2.30
RNA expression pattern
PBB GE PARP4 202239 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 143 328417
Ensembl ENSG00000102699 ENSMUSG00000054509
UniProt Q9UKK3 E9PYK3
RefSeq (mRNA) NM_006437 NM_001145978
RefSeq (protein) NP_006428 NP_001139450
Location (UCSC) Chr 13:
25 – 25.09 Mb
Chr 14:
56.58 – 56.66 Mb
PubMed search [1] [2]

Poly [ADP-ribose] polymerase 4 is an enzyme that in humans is encoded by the PARP4 gene.[1][2]

This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.[2]

Interactions[edit]

PARP4 has been shown to interact with Major vault protein.[3][4]

References[edit]

  1. ^ Still IH, Vince P, Cowell JK (Mar 2000). "Identification of a novel gene (ADPRTL1) encoding a potential Poly(ADP-ribosyl)transferase protein". Genomics 62 (3): 533–6. doi:10.1006/geno.1999.6024. PMID 10644454. 
  2. ^ a b "Entrez Gene: PARP4 poly (ADP-ribose) polymerase family, member 4". 
  3. ^ van Zon, Arend; Mossink Marieke H, Schoester Martijn, Scheffer George L, Scheper Rik J, Sonneveld Pieter, Wiemer Erik A C (Mar 2002). "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly". Biochem. Biophys. Res. Commun. (United States) 291 (3): 535–41. doi:10.1006/bbrc.2002.6472. ISSN 0006-291X. PMID 11855821. 
  4. ^ Kickhoefer, V A; Siva A C, Kedersha N L, Inman E M, Ruland C, Streuli M, Rome L H (Sep 1999). "The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase". J. Cell Biol. (UNITED STATES) 146 (5): 917–28. doi:10.1083/jcb.146.5.917. ISSN 0021-9525. PMC 2169495. PMID 10477748. 

Further reading[edit]