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Pleckstrin homology-like domain, family A, member 1
Symbols PHLDA1 ; DT1P1B11; PHRIP; TDAG51
External IDs OMIM605335 MGI1096880 HomoloGene7203 GeneCards: PHLDA1 Gene
RNA expression pattern
PBB GE PHLDA1 217996 at tn.png
PBB GE PHLDA1 217997 at tn.png
PBB GE PHLDA1 218000 s at tn.png
More reference expression data
Species Human Mouse
Entrez 22822 21664
Ensembl ENSG00000139289 ENSMUSG00000020205
UniProt Q8WV24 Q62392
RefSeq (mRNA) NM_007350 NM_009344
RefSeq (protein) NP_031376 NP_033370
Location (UCSC) Chr 12:
76.42 – 76.43 Mb
Chr 10:
111.51 – 111.51 Mb
PubMed search [1] [2]

Pleckstrin homology-like domain family A member 1 is a protein that in humans is encoded by the PHLDA1 gene.[1][2][3]

This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1.[3]


PHLDA1 has been shown to interact with RPL14,[4] EIF3D[4] and PABPC4.[4]


  1. ^ Neef R, Kuske MA, Prols E, Johnson JP (Oct 2002). "Identification of the human PHLDA1/TDAG51 gene: down-regulation in metastatic melanoma contributes to apoptosis resistance and growth deregulation". Cancer Res 62 (20): 5920–9. PMID 12384558. 
  2. ^ Toyoshima Y, Karas M, Yakar S, Dupont J, Lee Helman, LeRoith D (Jun 2004). "TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival". J Biol Chem 279 (24): 25898–904. doi:10.1074/jbc.M400661200. PMID 15037619. 
  3. ^ a b "Entrez Gene: PHLDA1 pleckstrin homology-like domain, family A, member 1". 
  4. ^ a b c Hinz, T; Flindt S; Marx A; Janssen O; Kabelitz D (May 2001). "Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product". Cell. Signal. (England) 13 (5): 345–52. doi:10.1016/S0898-6568(01)00141-3. ISSN 0898-6568. PMID 11369516. 

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