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Polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
Symbols POLR2B ; POL2RB; RPB2; hRPB140; hsRPB2
External IDs OMIM180661 MGI2388280 HomoloGene722 GeneCards: POLR2B Gene
EC number
RNA expression pattern
PBB GE POLR2B 201803 at tn.png
More reference expression data
Species Human Mouse
Entrez 5431 231329
Ensembl ENSG00000047315 ENSMUSG00000029250
UniProt P30876 Q8CFI7
RefSeq (mRNA) NM_000938 NM_153798
RefSeq (protein) NP_000929 NP_722493
Location (UCSC) Chr 4:
57.84 – 57.9 Mb
Chr 5:
77.31 – 77.35 Mb
PubMed search [1] [2]

DNA-directed RNA polymerase II subunit RPB2 is an enzyme that in humans is encoded by the POLR2B gene.[1][2]

This gene encodes the second largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with at least two other polymerase subunits, forms a structure within the polymerase that maintains contact in the active site of the enzyme between the DNA template and the newly synthesized RNA.[3]


POLR2B has been shown to interact with POLR2C,[4] POLR2E,[4] POLR2H[4] and POLR2L.[4]


  1. ^ Acker J, Wintzerith M, Vigneron M, Kedinger C (October 1992). "Primary structure of the second largest subunit of human RNA polymerase II (or B)". J Mol Biol 226 (4): 1295–9. doi:10.1016/0022-2836(92)91071-V. PMID 1518060. 
  2. ^ Acker J, Mattei MG, Wintzerith M, Roeckel N, Depetris D, Vigneron M, Kedinger C (August 1994). "Chromosomal localization of human RNA polymerase II subunit genes". Genomics 20 (3): 496–9. doi:10.1006/geno.1994.1208. PMID 8034326. 
  3. ^ "Entrez Gene: POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa". 
  4. ^ a b c d Acker, J; de Graaff M; Cheynel I; Khazak V; Kedinger C; Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. (UNITED STATES) 272 (27): 16815–21. doi:10.1074/jbc.272.27.16815. ISSN 0021-9258. PMID 9201987. 

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