PPP1R12A

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Protein phosphatase 1, regulatory subunit 12A
Protein PPP1R12A PDB 1s70.png
PDB rendering based on 1s70.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PPP1R12A ; M130; MBS; MYPT1
External IDs OMIM602021 MGI1309528 HomoloGene1855 ChEMBL: 3124 GeneCards: PPP1R12A Gene
RNA expression pattern
PBB GE PPP1R12A 201603 at tn.png
PBB GE PPP1R12A 201602 s at tn.png
PBB GE PPP1R12A 201604 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4659 17931
Ensembl ENSG00000058272 ENSMUSG00000019907
UniProt O14974 Q9DBR7
RefSeq (mRNA) NM_001143885 NM_027892
RefSeq (protein) NP_001137357 NP_082168
Location (UCSC) Chr 12:
80.17 – 80.33 Mb
Chr 10:
108.16 – 108.28 Mb
PubMed search [1] [2]

Protein phosphatase 1 regulatory subunit 12A is an enzyme that in humans is encoded by the PPP1R12A gene.[1][2]

Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle [3] and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase.[2]

Interactions[edit]

PPP1R12A has been shown to interact with Interleukin 16.[4]

References[edit]

  1. ^ Takahashi N, Ito M, Tanaka J, Nakano T, Kaibuchi K, Odai H, Takemura K (Nov 1997). "Localization of the gene coding for myosin phosphatase, target subunit 1 (MYPT1) to human chromosome 12q15-q21". Genomics 44 (1): 150–2. doi:10.1006/geno.1997.4859. PMID 9286714. 
  2. ^ a b "Entrez Gene: PPP1R12A protein phosphatase 1, regulatory (inhibitor) subunit 12A". 
  3. ^ Michael P. Walsh, et all. "Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855 but not Thr-697". 
  4. ^ Bannert, Norbert; Vollhardt Karin, Asomuddinov Bakhtier, Haag Marion, König Herbert, Norley Stephen, Kurth Reinhard (Oct 2003). "PDZ Domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits". J. Biol. Chem. (United States) 278 (43): 42190–9. doi:10.1074/jbc.M306669200. ISSN 0021-9258. PMID 12923170. 

Further reading[edit]

External links[edit]