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Protein arginine methyltransferase 2
Protein PRMT2 PDB 1x2p.png
PDB rendering based on 1x2p.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PRMT2 ; HRMT1L1
External IDs OMIM601961 MGI1316652 HomoloGene55587 GeneCards: PRMT2 Gene
EC number
RNA expression pattern
PBB GE PRMT2 202098 s at tn.png
PBB GE PRMT2 210384 at tn.png
More reference expression data
Species Human Mouse
Entrez 3275 15468
Ensembl ENSG00000160310 ENSMUSG00000020230
UniProt P55345 E9QP78
RefSeq (mRNA) NM_001242864 NM_001077638
RefSeq (protein) NP_001229793 NP_001071106
Location (UCSC) Chr 21:
48.06 – 48.09 Mb
Chr 10:
76.21 – 76.24 Mb
PubMed search [1] [2]

Protein arginine N-methyltransferase 2 is an enzyme that in humans is encoded by the PRMT2 gene.[1][2]


PRMT2 has been shown to interact with Estrogen receptor alpha[3] and HNRPUL1.[4]


  1. ^ Scott HS, Antonarakis SE, Lalioti MD, Rossier C, Silver PA, Henry MF (Jun 1998). "Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2)". Genomics 48 (3): 330–40. doi:10.1006/geno.1997.5190. PMID 9545638. 
  2. ^ "Entrez Gene: PRMT2 protein arginine methyltransferase 2". 
  3. ^ Qi, Chao; Chang Jeffrey; Zhu Yiwei; Yeldandi Anjana V; Rao Sambasiva M; Zhu Yi-Jun (Aug 2002). "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha". J. Biol. Chem. (United States) 277 (32): 28624–30. doi:10.1074/jbc.M201053200. ISSN 0021-9258. PMID 12039952. 
  4. ^ Kzhyshkowska, J; Schütt H; Liss M; Kremmer E; Stauber R; Wolf H; Dobner T (Sep 2001). "Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1". Biochem. J. (England) 358 (Pt 2): 305–14. doi:10.1042/0264-6021:3580305. ISSN 0264-6021. PMC 1222062. PMID 11513728. 

Further reading[edit]