Pre-B cell

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A Pre-B cell is a precursor to the development of B cells.[1]

Certain leukemias/lymphomas are associated with immature B cells, and observing pre-B cell populations can be useful in the identification of these conditions.

It expresses CD19 and CD127, and the immunoglobulin heavy chain is rearranged, but the immunoglobulin light chain is not yet rearranged at this stage.

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  1. ^ Rossi B, Espeli M, Schiff C, Gauthier L (July 2006). "Clustering of pre-B cell integrins induces galectin-1-dependent pre-B cell receptor relocalization and activation". J. Immunol. 177 (2): 796–803. PMID 16818733. 

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