Ras-related protein Rab-7a is a protein that in humans is encoded by the RAB7Agene.
Members of the RAB family of RAS-related GTP-binding proteins are important regulators of vesicular transport and are located in specific intracellular compartments. RAB7 has been localized to late endosomes and shown to be important in the late endocytic pathway. In addition, it has been shown to have a fundamental role in the cellular vacuolation induced by the cytotoxin VacA of Helicobacter pylori.[supplied by OMIM]
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^Rak, Alexey; Pylypenko Olena, Niculae Anca, Goody Roger S, Alexandrov Kirill (January 2003). "Crystallization and preliminary X-ray diffraction analysis of monoprenylated Rab7 GTPase in complex with Rab escort protein 1". J. Struct. Biol. (United States) 141 (1): 93–5. doi:10.1016/S1047-8477(02)00634-2. ISSN1047-8477. PMID12576024.Cite uses deprecated parameters (help)
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