RBPMS

RBPMS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5DET, 5CYJ
Identifiers
Aliases	RBPMS, HERMES, RNA binding protein with multiple splicing, RNA binding protein, mRNA processing factor
External IDs	OMIM: 601558 MGI: 1334446 HomoloGene: 38238 GeneCards: RBPMS
Gene location (Human)
Chr.	Chromosome 8 (human)
End	30,572,256 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	34,419,891 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; gastric mucosa; ; right coronary artery; ; thoracic aorta; ; ascending aorta; ; left coronary artery; ; canal of the cervix; ; right lobe of thyroid gland; ; left uterine tube; ; left lobe of thyroid gland;
	Top expressed in
	ascending aorta; ; aortic valve; ; atrium; ; interventricular septum; ; right ventricle; ; myocardium of ventricle; ; uterus; ; morula; ; yolk sac; ; atrioventricular valve;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transcription coactivator activity; protein binding; poly(A) binding; nucleic acid binding; protein homodimerization activity; RNA binding; U1 snRNA binding; snRNA stem-loop binding; mRNA binding;
Cellular component	nucleus; nucleoplasm; P-body; cytoplasmic stress granule; U1 snRNP; cytoplasm; cytosol;
Biological process	positive regulation of pathway-restricted SMAD protein phosphorylation; RNA processing; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of SMAD protein signal transduction; response to oxidative stress; mRNA splicing, via spliceosome; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	11030
	19663
	ENSG00000157110
	ENSMUSG00000031586
	Q93062
	Q9WVB0
	NM_001008710; NM_001008711; NM_001008712; NM_006867
	NM_001042674; NM_001042675; NM_001286168; NM_019733
	NP_001008710; NP_001008711; NP_001008712; NP_006858
	NP_001036139; NP_001036140; NP_001273097; NP_062707
	Wikidata
View/Edit Human	View/Edit Mouse

RNA-binding protein with multiple splicing is a protein that in humans is encoded by the RBPMS gene.^[5]^[6]

Function[edit]

This gene encodes a member of the RRM family of RNA-binding proteins. The RRM domain is between 80-100 amino acids in length and family members contain one to four copies of the domain. The RRM domain consists of two short stretches of conserved sequence called RNP1 and RNP2, as well as a few highly conserved hydrophobic residues. The protein encoded by this gene has a single, putative RRM domain in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms.^[6]

It is uniquely expressed in retinal ganglion cells in the mammalian retina,^[7] for reasons unknown.

Interactions[edit]

RBPMS has been shown to interact with SMUG1.^[8]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000157110 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031586 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shimamoto A, Kitao S, Ichikawa K, Suzuki N, Yamabe Y, Imamura O, Tokutake Y, Satoh M, Matsumoto T, Kuromitsu J, Kataoka H, Sugawara K, Sugawara M, Sugimoto M, Goto M, Furuichi Y (Nov 1996). "A unique human gene that spans over 230 kb in the human chromosome 8p11-12 and codes multiple family proteins sharing RNA-binding motifs". Proc. Natl. Acad. Sci. U.S.A. 93 (20): 10913–7. Bibcode:1996PNAS...9310913S. doi:10.1073/pnas.93.20.10913. PMC 38257. PMID 8855282.
^ ^a ^b "Entrez Gene: RBPMS RNA binding protein with multiple splicing".
^ Rodriguez AR, de Sevilla Müller LP, Brecha NC (Mar 2014). "The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina". J. Comp. Neurol. 522 (6): 1411–43. doi:10.1002/cne.23521. PMC 3959221. PMID 24318667.
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading[edit]

Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Hillman RT, Green RE, Brenner SE (2004). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000157110 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031586 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8855282-5] Shimamoto A, Kitao S, Ichikawa K, Suzuki N, Yamabe Y, Imamura O, Tokutake Y, Satoh M, Matsumoto T, Kuromitsu J, Kataoka H, Sugawara K, Sugawara M, Sugimoto M, Goto M, Furuichi Y (Nov 1996). "A unique human gene that spans over 230 kb in the human chromosome 8p11-12 and codes multiple family proteins sharing RNA-binding motifs". Proc. Natl. Acad. Sci. U.S.A. 93 (20): 10913–7. Bibcode:1996PNAS...9310913S. doi:10.1073/pnas.93.20.10913. PMC 38257. PMID 8855282.

[entrez-6] "Entrez Gene: RBPMS RNA binding protein with multiple splicing".

[pmid24318667-7] Rodriguez AR, de Sevilla Müller LP, Brecha NC (Mar 2014). "The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina". J. Comp. Neurol. 522 (6): 1411–43. doi:10.1002/cne.23521. PMC 3959221. PMID 24318667.

[pmid16189514-8] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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