RNF25

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Ring finger protein 25
Protein RNF25 PDB 2day.png
PDB rendering based on 2day.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RNF25 ; AO7
External IDs MGI1890215 HomoloGene11193 GeneCards: RNF25 Gene
RNA expression pattern
PBB GE RNF25 218861 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 64320 57751
Ensembl ENSG00000163481 ENSMUSG00000026171
UniProt Q96BH1 Q9QZR0
RefSeq (mRNA) NM_022453 NM_021313
RefSeq (protein) NP_071898 NP_067288
Location (UCSC) Chr 2:
219.53 – 219.54 Mb
Chr 1:
74.59 – 74.6 Mb
PubMed search [1] [2]

E3 ubiquitin-protein ligase RNF25 is an enzyme that in humans is encoded by the RNF25 gene.[1][2]

The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination.[2]

Interactions[edit]

RNF25 has been shown to interact with RELA.[1]

References[edit]

  1. ^ a b Asamitsu K, Tetsuka T, Kanazawa S, Okamoto T (Jul 2003). "RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit". J Biol Chem 278 (29): 26879–87. doi:10.1074/jbc.M211831200. PMID 12748188. 
  2. ^ a b "Entrez Gene: RNF25 ring finger protein 25". 

Further reading[edit]