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Ring finger protein 25
Protein RNF25 PDB 2day.png
PDB rendering based on 2day.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RNF25 ; AO7
External IDs MGI1890215 HomoloGene11193 GeneCards: RNF25 Gene
RNA expression pattern
PBB GE RNF25 218861 at tn.png
More reference expression data
Species Human Mouse
Entrez 64320 57751
Ensembl ENSG00000163481 ENSMUSG00000026171
UniProt Q96BH1 Q9QZR0
RefSeq (mRNA) NM_022453 NM_021313
RefSeq (protein) NP_071898 NP_067288
Location (UCSC) Chr 2:
219.53 – 219.54 Mb
Chr 1:
74.59 – 74.6 Mb
PubMed search [1] [2]

E3 ubiquitin-protein ligase RNF25 is an enzyme that in humans is encoded by the RNF25 gene.[1][2]


The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination.[2]


RNF25 has been shown to interact with RELA.[1]


  1. ^ a b Asamitsu K, Tetsuka T, Kanazawa S, Okamoto T (Jul 2003). "RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit". J. Biol. Chem. 278 (29): 26879–87. doi:10.1074/jbc.M211831200. PMID 12748188. 
  2. ^ a b "Entrez Gene: RNF25 ring finger protein 25". 

Further reading[edit]