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Rajendra Kumar Sharma

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Rajendra Kumar Sharma
SOM FRSA
Born (1942-01-02) January 2, 1942 (age 82)
Hathras, Hathras district, Uttar Pradesh, India
EducationD.Sc. in pathology, Ph.D. in biochemistry
Alma mater
Occupation(s)Professor, research scientist
Years activeSince 1970
EmployerUniversity of Saskatchewan
Known forCalmodulin regulated systems and myristoylation of cellular proteins
Awards

Rajendra Kumar Sharma SOM FRSA (born January 2, 1942) is a professor at the Department of Pathology and Laboratory Medicine, University of Saskatchewan College of Medicine.[1] He holds an earned Doctor of Science from the University of Saskatchewan,[2] and was elected a Fellow of the Royal Society of the Arts (FRSA) in 2014.[3] His contributions to research have been documented in the Encyclopedia of Saskatchewan – A Living Legacy.[4] Sharma has made several discoveries in the areas of colorectal cancer and the cardiovascular system.

Biography

Rajendra Sharma, the son of Venkateswar Sharma and Durga Devi Sharma, was born on January 2, 1942, in Hathras, Uttar Pradesh, India. He spent his childhood in Hathras where he studied primary education at Mohan Gunj Primary Municipality School and higher secondary education at Saraswati Inter College. Sharma completed his B.Sc. in Chemistry, Botany and Zoology in 1963 and M.Sc. in Biochemistry in 1965 from Aligarh Muslim University. He served as a chemistry lecturer at Saraswati Inter College due to the shortage of chemistry teachers during 1965. He was awarded a research fellowship from the Council of Scientific and Industrial Research (CSIR) to pursue a Ph.D. degree in Biochemistry at the All India Institute of Medical Sciences (AIIMS), New Delhi, where he worked in the area of protein chemistry and enzymology. His Ph.D. research work was published in the Journal of Biological Chemistry.[5] After completing his Ph.D., Sharma worked as a lecturer at the Department of Biochemistry, Lady Hardinge Medical College & Hospital, New Delhi.

Sharma married Manjul Saraswat in 1970; they have three daughters, Priya, Puja and Poonam.

Scientific career

Sharma pursued his postdoctoral research in the field of cancer biology in 1972 in the Department of Biochemistry & Pharmacology, Tufts University School of Medicine, Boston, Massachusetts, US.[6][7] In 1975, he joined the College of Medicine, University of South Alabama, as a research associate in the Department of Biochemistry. In 1976 he joined the Department of Biochemistry, Faculty of Medicine, University of Manitoba, in Winnipeg to pursue his further research career.[8][9] Later he moved to the Department of Medical Biochemistry, University of Calgary, Alberta and made several discoveries in the areas of signal transduction.[10][11][12][13] In 1991, Sharma joined as an associate professor at the Department of Pathology & Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon. In the year 2012, Sharma was awarded the title of a Distinguished Professor at the University of Saskatchewan[14][15] and he continues to serve at the same position to date.[16]

Sharma's research was primarily focused in the areas of calmodulin-regulated systems [17] and myristoylation of cellular proteins.[18] He was the first to report the role of N-myrstoyltransferase in colorectal cancer,[19] which was highlighted in the Journal of the National Cancer Institute.[20] His extensive research studies led to the identification of N-myrstoyltransferase as a potential biomarker in colorectal cancer patients.[21] This discovery was licensed for the development of a diagnostic tool to detect colorectal cancer.[22] Sharma's research has resulted in the identification and characterization of several proteins from various species related to colorectal cancer and cardiovascular system that has led to 265 full-length publications in reputed journals to his credit.[23] Sharma has also co-edited a book on signal transduction mechanisms.[24] He is also currently serving as the Editor-In-Chief of a peer-reviewed international scientific journal entitled "Journal of Molecular Biology & Therapeutics".[25] Recently an article on his decades of dedication to research was published in OCN (ON CAMPUS NEWS) at the University of Saskatchewan.[26]

Recognitions

The City of Saskatoon, Saskatchewan, named four streets in Aspen Ridge in recognition of Sharma's scholarly contributions to science and research.[31]

References

  1. ^ "Rajendra Sharma - College of Medicine, University of Saskatchewan". medicine.usask.ca. Retrieved January 15, 2018.
  2. ^ "Past recipients of earned degrees - College of Graduate and Postdoctoral Studies, University of Saskatchewan". www.usask.ca. Retrieved January 15, 2018.
  3. ^ RSA. "Find a Fellow - RSA". www.thersa.org. Retrieved January 15, 2018.
  4. ^ THE ENCYCLOPEDIA OF SASKATCHEWAN a Living Legacy. Regina: Canadian Plains Research Center. 2005.
  5. ^ Mazumder, Rajarshi; Sharma, Rajendra K. (1970). "Purification, Properties, and Feedback Control of l-Threonine Dehydratase from Spinach". Journal of Biological Chemistry. 245 (11): 3008–3014. doi:10.1016/S0021-9258(18)63089-3. PMID 5423384.
  6. ^ Sharma, Rajendra K.; Kisliuk, Roy L.; Verma, Surendra P.; Wallach, Donald F.H. (1975). "Study of thymidylate synthetase-function by laser Raman spectroscopy". Biochimica et Biophysica Acta (BBA) - Enzymology. 391 (1): 19–27. doi:10.1016/0005-2744(75)90148-5. ISSN 0005-2744. PMID 806300.
  7. ^ Sharma, R.K.; Kisliuk, R.L. (1975). "Quenching of thymidylate synthetases fluorescence by substrate analogs". Biochem Biophys Res Commun. 64 (2): 648–655. doi:10.1016/0006-291X(75)90370-8. PMID 125086.
  8. ^ Sharma, RK; Wirch, E; Wang, JH (May 25, 1978). "Inhibition of Ca2+-activated cyclic nucleotide phosphodiesterase reaction by a heat-stable inhibitor protein from bovine brain". The Journal of Biological Chemistry. 253 (10): 3575–80. doi:10.1016/S0021-9258(17)34840-8. PMID 206547.
  9. ^ Sharma, RK; Tam, SW; Waisman, DM; Wang, JH (December 10, 1980). "Differential interaction of rabbit skeletal muscle phosphorylase kinase isozymes with calmodulin". The Journal of Biological Chemistry. 255 (23): 11102–3. doi:10.1016/S0021-9258(19)70260-9. PMID 6777374.
  10. ^ Huang, C. Y.; Chau, V.; Chock, P. B.; Wang, J. H.; Sharma, R. K. (1982). "Mechanism of activation of cyclic nucleotide phosphodiesterase: requirement of the binding of four Ca2+ to calmodulin for activation". Proc Natl Acad Sci USA. 78 (2): 874–876. doi:10.1073/pnas.78.2.871. PMC 319905. PMID 6262778.
  11. ^ Sharma, R. K.; Adachi, A. M.; Adachi, K.; Wang, J. H. (1984). "Demonstration of bovine brain calmodulin dependent cyclic nucleotide phosphodiesterase isozymes by monoclonal antibodies". J Biol Chem. 259 (14): 9248–9254. doi:10.1016/S0021-9258(17)47292-9. PMID 6086630.
  12. ^ Sharma, R. K.; Wang, J. H. (1985). "Differential regulation of bovine brain calmodulin dependent cyclic nucleotide phosphodiesterase isozyme by cyclic AMP-dependent protein kinase and calmodulin-dependent phosphatase". Proc Natl Acad Sci USA. 82 (9): 2603–2607. Bibcode:1985PNAS...82.2603S. doi:10.1073/pnas.82.9.2603. PMC 397612. PMID 2986124.
  13. ^ Sharma, R. K. (1990). "Purification and characterization of novel calmodulin binding protein from cardiac muscle". J Biol Chem. 265 (2): 1152–7. doi:10.1016/S0021-9258(19)40171-3. PMID 2295605.
  14. ^ "Distinguished Professorship Program".
  15. ^ "Distinguished Professorship Recipients" (PDF).
  16. ^ "Distinguished Professor".
  17. ^ Parameswaran, S; Sharma, RK (August 2012). "High molecular weight calmodulin-binding protein: 20 years onwards-a potential therapeutic calpain inhibitor". Cardiovascular Drugs and Therapy. 26 (4): 321–30. doi:10.1007/s10557-012-6399-8. PMID 22588788. S2CID 22528531.
  18. ^ Selvakumar, P; Lakshmikuttyamma, A; Shrivastav, A; Das, SB; Dimmock, JR; Sharma, RK (January 2007). "Potential role of N-myristoyltransferase in cancer". Progress in Lipid Research. 46 (1): 1–36. doi:10.1016/j.plipres.2006.05.002. PMID 16846646.
  19. ^ Magnuson, B. A.; Raju, R. V. S.; Moyana, T. N.; Sharma, R. K. (1995). "Increased N -Myristoyltransferase Activity Observed in Rat and Human Colonic Tumors". J. Natl. Cancer Inst. 87 (21): 1630–1635. doi:10.1093/jnci/87.21.1630. PMID 7563206.
  20. ^ Felsted, R. L.; Glover, C. J.; Hartman, K. (1995). "Protein N-Myristoylation as a Chemotherapeutic Target for Cancer". J. Natl. Cancer Inst. 87 (21): 1571–1573. doi:10.1093/jnci/87.21.1571. PMID 7563194.
  21. ^ Shrivastav, Anuraag; Varma, Shailly; Saxena, Anurag; Decoteau, John; Sharma, Rajendra K. (2007). "N-myristoyltransferase: A potential novel diagnostic marker for colon cancer". J. Transl. Med. 5: 58. doi:10.1186/1479-5876-5-58. PMC 2203986. PMID 18021392.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  22. ^ Sharma, R.K. and Shrivastav, A. "Use of N-myristoyltransferase on non-tumor tissue for cancer diagnosis". Retrieved May 15, 2018.{{cite web}}: CS1 maint: multiple names: authors list (link)
  23. ^ "Rajenda K. Sharma - Google Scholar Citations". scholar.google.ca.
  24. ^ Barnes, Junor A; Coore, Haldane G; Mohammed, Abdul H; Sharma, Rajendra K, eds. (1995). Signal Transduction Mechanisms. Developments in Molecular and Cellular Biochemistry. Springer. doi:10.1007/978-1-4615-2015-3. ISBN 9780792336631. S2CID 26525644. Retrieved May 15, 2018.
  25. ^ "Journal of Molecular Biology & Therapeutics | Innova Publications". innovapublications.com. Retrieved August 20, 2019.
  26. ^ "Celebrating Sharma's record of research". News. Retrieved August 20, 2019.
  27. ^ "Saskatchewan Order of Merit | Saskatchewan Heritage, Honours, and Awards | Government of Saskatchewan". Government of Saskatchewan. Retrieved January 15, 2018.
  28. ^ "On Campus News". news.usask.ca. Retrieved January 15, 2018.
  29. ^ "Rajendra Sharma, S.O.M., Ph.D., D.Sc. | The Governor General of Canada". Office of the Governor General of Canada. Retrieved November 15, 2018.
  30. ^ RSA. "Find a Fellow - RSA". www.thersa.org. Retrieved January 15, 2018.
  31. ^ "ASPEN RIDGE NEIGHBOURHOOD CONCEPT PLAN".
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