Regis is a neighborhood in Denver. It is located in the area known as North Denver. Its boundaries are Harlan Street to the west, Clear Creek (Colorado) to the northwest, 52nd Avenue and the northern border of the Regis University campus to the north, Federal Boulevard to the east, and highway I-70 to the south. Located in the neighborhood is Regis University and the Willis Case golf course.
The neighborhood is located in the extreme northwest part of Denver. The neighborhood includes a well established residential area with commercial centers located along the major traffic route of Federal Blvd. to the east.