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Scavenger receptor class B, member 2
4f7b 1.png
Structure of the lysosomal domain of limp-2. PDB entry 4f7b
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM602257 MGI1196458 HomoloGene48353 GeneCards: SCARB2 Gene
RNA expression pattern
PBB GE SCARB2 201647 s at tn.png
PBB GE SCARB2 201646 at tn.png
More reference expression data
Species Human Mouse
Entrez 950 12492
Ensembl ENSG00000138760 ENSMUSG00000029426
UniProt Q14108 O35114
RefSeq (mRNA) NM_001204255 NM_007644
RefSeq (protein) NP_001191184 NP_031670
Location (UCSC) Chr 4:
77.08 – 77.14 Mb
Chr 5:
92.44 – 92.51 Mb
PubMed search [1] [2]

Lysosome membrane protein 2 is a protein that in humans is encoded by the SCARB2 gene.[1][2]

The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Studies of the similar protein in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. Deficiency of the similar protein in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy.[2]

Clinical significance[edit]

SCARB2 is a receptor for two viruses that cause hand, foot, and mouth disease in children, Enterovirus 71 and Coxsackievirus A16.[3]


  1. ^ Fujita H, Takata Y, Kono A, Tanaka Y, Takahashi T, Himeno M, Kato K (Jun 1992). "Isolation and sequencing of a cDNA clone encoding the 85 kDa human lysosomal sialoglycoprotein (hLGP85) in human metastatic pancreas islet tumor cells". Biochem Biophys Res Commun 184 (2): 604–11. doi:10.1016/0006-291X(92)90632-U. PMID 1374238. 
  2. ^ a b "Entrez Gene: SCARB2 scavenger receptor class B, member 2". 
  3. ^ Yamayoshi S, Yamashita Y, Li J, Hanagata N, Minowa T, Takemura T, Koike S (July 2009). "Scavenger receptor B2 is a cellular receptor for enterovirus 71". Nat. Med. 15 (7): 798–801. doi:10.1038/nm.1992. PMID 19543282. 

Further reading[edit]