SKBR3

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SkBr3 is a cell line isolated by the Memorial Sloan–Kettering Cancer Center in 1970. It was derived from a pleural effusion due to an adenocarcinoma originating in the breast of a 43-year-old, caucasian female. The cell line over-expresses the HER2 gene product. [1]

The SkBr3 line is synonymous(derived from the same patient) with the AU565 cell line.[2]

The SkBr3 cell line has been used in studies seeking to overcome Herceptin resistance to HER2-overexpressing breast cancer.[3]

The cells are considered biosafety level 1.[1]

References

  1. ^ a b "ATCC Product Description". Retrieved 26 February 2012.
  2. ^ "LBL Breast Cancer Cell Collection: Cell Line AU565". Retrieved 26 February 2012.
  3. ^ "Overcoming Trastuzumab Resistance in HER2-Overexpressing Breast Cancer Cells by Using a Novel Celecoxib-Derived Phosphoinositide-Dependent Kinase-1 Inhibitor". Retrieved 26 February 2012.

External links

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