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SNW domain containing 1
Symbols SNW1 ; Bx42; NCOA-62; PRPF45; Prp45; SKIIP; SKIP
External IDs OMIM603055 HomoloGene56557 GeneCards: SNW1 Gene
RNA expression pattern
PBB GE SNW1 201575 at tn.png
PBB GE SNW1 215424 s at tn.png
More reference expression data
Species Human Mouse
Entrez 22938 66354
Ensembl ENSG00000100603 ENSMUSG00000021039
UniProt Q13573 Q9CSN1
RefSeq (mRNA) NM_012245 NM_025507
RefSeq (protein) NP_036377 NP_079783
Location (UCSC) Chr 14:
78.18 – 78.23 Mb
Chr 12:
87.45 – 87.47 Mb
PubMed search [1] [2]

SNW domain-containing protein 1 is a protein that in humans is encoded by the SNW1 gene.[1][2][3]

This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.[3]


SNW1 has been shown to interact with Histone deacetylase 2,[4] SKI protein,[5][6][7] Retinoblastoma protein,[8] PABPN1,[9] CIR,[4] RBPJ,[4][10] Nuclear receptor coactivator 1,[11] Nuclear receptor co-repressor 2,[4][10] Calcitriol receptor,[2][11] Mothers against decapentaplegic homolog 3,[7] NOTCH1[10][12] and Mothers against decapentaplegic homolog 2.[7]


  1. ^ Folk P, Puta F, Krpejsova L, Blahuskova A, Markos A, Rabino M, Dottin RP (January 1997). "The homolog of chromatin binding protein Bx42 identified in Dictyostelium". Gene 181 (1–2): 229–31. doi:10.1016/S0378-1119(96)00483-0. PMID 8973337. 
  2. ^ a b Baudino TA, Kraichely DM, Jefcoat SC Jr, Winchester SK, Partridge NC, MacDonald PN (August 1998). "Isolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcription". J Biol Chem 273 (26): 16434–41. doi:10.1074/jbc.273.26.16434. PMID 9632709. 
  3. ^ a b "Entrez Gene: SNW1 SNW domain containing 1". 
  4. ^ a b c d Zhou, S; Fujimuro M; Hsieh J J; Chen L; Hayward S D (February 2000). "A Role for SKIP in EBNA2 Activation of CBF1-Repressed Promoters". J. Virol. (UNITED STATES) 74 (4): 1939–47. doi:10.1128/JVI.74.4.1939-1947.2000. ISSN 0022-538X. PMC 111672. PMID 10644367. 
  5. ^ Prathapam, T; Kühne C; Hayman M; Banks L (September 2001). "Ski interacts with the evolutionarily conserved SNW domain of Skip". Nucleic Acids Res. (England) 29 (17): 3469–76. doi:10.1093/nar/29.17.3469. PMC 55893. PMID 11522815. 
  6. ^ Dahl, R; Wani B; Hayman M J (March 1998). "The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42". Oncogene (ENGLAND) 16 (12): 1579–86. doi:10.1038/sj.onc.1201687. ISSN 0950-9232. PMID 9569025. 
  7. ^ a b c Leong, G M; Subramaniam N; Figueroa J; Flanagan J L; Hayman M J; Eisman J A; Kouzmenko A P (May 2001). "Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription". J. Biol. Chem. (United States) 276 (21): 18243–8. doi:10.1074/jbc.M010815200. ISSN 0021-9258. PMID 11278756. 
  8. ^ Prathapam, Tulasiram; Kühne Christian; Banks Lawrence (Dec 2002). "Skip interacts with the retinoblastoma tumor suppressor and inhibits its transcriptional repression activity". Nucleic Acids Res. (England) 30 (23): 5261–8. doi:10.1093/nar/gkf658. PMC 137971. PMID 12466551. 
  9. ^ Kim, Y J; Noguchi S; Hayashi Y K; Tsukahara T; Shimizu T; Arahata K (May 2001). "The product of an oculopharyngeal muscular dystrophy gene, poly(A)-binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression". Hum. Mol. Genet. (England) 10 (11): 1129–39. doi:10.1093/hmg/10.11.1129. ISSN 0964-6906. PMID 11371506. 
  10. ^ a b c Zhou, S; Fujimuro M; Hsieh J J; Chen L; Miyamoto A; Weinmaster G; Hayward S D (April 2000). "SKIP, a CBF1-Associated Protein, Interacts with the Ankyrin Repeat Domain of NotchIC To Facilitate NotchIC Function". Mol. Cell. Biol. (UNITED STATES) 20 (7): 2400–10. doi:10.1128/MCB.20.7.2400-2410.2000. ISSN 0270-7306. PMC 85419. PMID 10713164. 
  11. ^ a b Zhang, C; Baudino T A; Dowd D R; Tokumaru H; Wang W; MacDonald P N (November 2001). "Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription". J. Biol. Chem. (United States) 276 (44): 40614–20. doi:10.1074/jbc.M106263200. ISSN 0021-9258. PMID 11514567. 
  12. ^ Beatus, P; Lundkvist J; Oberg C; Pedersen K; Lendahl U (June 2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mech. Dev. (Ireland) 104 (1–2): 3–20. doi:10.1016/S0925-4773(01)00373-2. ISSN 0925-4773. PMID 11404076. 

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