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Serine peptidase inhibitor, Kunitz type, 2
Symbols SPINT2 ; DIAR3; HAI-2; HAI2; Kop; PB
External IDs OMIM605124 MGI1338031 HomoloGene7955 GeneCards: SPINT2 Gene
RNA expression pattern
PBB GE SPINT2 210715 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10653 20733
Ensembl ENSG00000167642 ENSMUSG00000074227
UniProt O43291 Q9WU03
RefSeq (mRNA) NM_001166103 NM_001082548
RefSeq (protein) NP_001159575 NP_001076017
Location (UCSC) Chr 19:
38.73 – 38.78 Mb
Chr 7:
29.26 – 29.28 Mb
PubMed search [1] [2]

Kunitz-type protease inhibitor 2 is an enzyme that in humans is encoded by the SPINT2 gene.[1][2][3]


  1. ^ Marlor CW, Delaria KA, Davis G, Muller DK, Greve JM, Tamburini PP (Jun 1997). "Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domains". J Biol Chem 272 (18): 12202–8. doi:10.1074/jbc.272.18.12202. PMID 9115294. 
  2. ^ Kawaguchi T, Qin L, Shimomura T, Kondo J, Matsumoto K, Denda K, Kitamura N (Dec 1997). "Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor". J Biol Chem 272 (44): 27558–64. doi:10.1074/jbc.272.44.27558. PMID 9346890. 
  3. ^ "Entrez Gene: SPINT2 serine peptidase inhibitor, Kunitz type, 2". 

Further reading[edit]

  • Morelle W; Capon C; Balduyck M et al. (1994). "Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor". Eur. J. Biochem. 221 (2): 881–8. doi:10.1111/j.1432-1033.1994.tb18803.x. PMID 7513643. 
  • Mizon C; Balduyck M; Albani D et al. (1996). "Development of an enzyme-linked immunosorbent assay for human plasma inter-alpha-trypsin inhibitor (ITI) using specific antibodies against each of the H1 and H2 heavy chains". J. Immunol. Methods 190 (1): 61–70. doi:10.1016/0022-1759(95)00257-X. PMID 8601712. 
  • Gress TM; Müller-Pillasch F; Geng M et al. (1996). "A pancreatic cancer-specific expression profile". Oncogene 13 (8): 1819–30. PMID 8895530. 
  • Shimomura T; Denda K; Kitamura A et al. (1997). "Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor". J. Biol. Chem. 272 (10): 6370–6. doi:10.1074/jbc.272.10.6370. PMID 9045658. 
  • Blom AM, Thuveson M, Fries E (1998). "Intracellular coupling of bikunin and the heavy chain of rat pre-alpha-inhibitor in COS-1 cells". Biochem. J. 328 ( Pt 1) (Pt 1): 185–91. PMC 1218904. PMID 9359851. 
  • Müller-Pillasch F; Wallrapp C; Bartels K et al. (1998). "Cloning of a new Kunitz-type protease inhibitor with a putative transmembrane domain overexpressed in pancreatic cancer". Biochim. Biophys. Acta 1395 (1): 88–95. doi:10.1016/s0167-4781(97)00129-2. PMID 9434156. 
  • Kataoka H; Shimomura T; Kawaguchi T et al. (2001). "Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment". J. Biol. Chem. 275 (51): 40453–62. doi:10.1074/jbc.M006412200. PMID 11013244. 
  • Itoh H; Kataoka H; Yamauchi M et al. (2001). "Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes". Biochem. Biophys. Res. Commun. 288 (2): 390–9. doi:10.1006/bbrc.2001.5767. PMID 11606055. 
  • Suzuki M; Kobayashi H; Fujie M et al. (2002). "Kunitz-type protease inhibitor bikunin disrupts phorbol ester-induced oligomerization of CD44 variant isoforms containing epitope v9 and subsequently suppresses expression of urokinase-type plasminogen activator in human chondrosarcoma cells". J. Biol. Chem. 277 (10): 8022–32. doi:10.1074/jbc.M108545200. PMID 11777908. 
  • Kobayashi H; Suzuki M; Kanayama N et al. (2002). "Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade". Eur. J. Biochem. 269 (16): 3945–57. doi:10.1046/j.1432-1033.2002.03068.x. PMID 12180971. 
  • Mizon C; Piva F; Queyrel V et al. (2003). "Urinary bikunin determination provides insight into proteinase/proteinase inhibitor imbalance in patients with inflammatory diseases". Clin. Chem. Lab. Med. 40 (6): 579–86. doi:10.1515/CCLM.2002.100. PMID 12211652. 
  • Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Isogai R; Matsukura A; Aragane Y et al. (2003). "Quantitative analysis of bikunin-laden mast cells in follicular eruptions and chronic skin lesions of atopic dermatitis". Arch. Dermatol. Res. 294 (9): 387–92. doi:10.1007/s00403-002-0336-9. PMID 12522575. 
  • Yamauchi M; Itoh H; Naganuma S et al. (2003). "Expression of hepatocyte growth factor activator inhibitor type 2 (HAI-2) in human testis: identification of a distinct transcription start site for the HAI-2 gene in testis". Biol. Chem. 383 (12): 1953–7. doi:10.1515/BC.2002.220. PMID 12553733. 
  • Suzuki M; Kobayashi H; Tanaka Y et al. (2003). "Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cell line by overexpression of bikunin". Int. J. Cancer 104 (3): 289–302. doi:10.1002/ijc.10950. PMID 12569552. 
  • Suzuki M; Kobayashi H; Tanaka Y et al. (2003). "Bikunin target genes in ovarian cancer cells identified by microarray analysis". J. Biol. Chem. 278 (17): 14640–6. doi:10.1074/jbc.M300239200. PMID 12571229. 
  • Schuster JM, Longo M, Nelson PS (2003). "Differential expression of bikunin (HAI-2/PB), a proposed mediator of glioma invasion, by demethylation treatment". J. Neurooncol. 64 (3): 219–25. doi:10.1023/A:1025674227750. PMID 14558597. 
  • Fukai K; Yokosuka O; Chiba T et al. (2004). "Hepatocyte growth factor activator inhibitor 2/placental bikunin (HAI-2/PB) gene is frequently hypermethylated in human hepatocellular carcinoma". Cancer Res. 63 (24): 8674–9. PMID 14695180.