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Slough is a town in Berkshire, England.
Slough may also refer to:
- a stream distributary or anabranch, or in some cases, a regular stream.
- a muddy marsh in the British Isles.
- a swamp or shallow lake system with trees (Eastern and South Eastern United States).
- a secondary channel of a river delta, without trees (Pacific coast of North America).
- a pond, often alkaline
Biology and medicine
- Yellow necrotic tissue referred to as slough.
- Slough (moulting), in animals, to shed the skin or shell
- Slough sedge, the grass-like plant Carex obnupta
- "Slough" (poem), by Sir John Betjeman about the town of Slough
- Slough of Despond, fictional bog originally featured in A Pilgrim's Progress by John Bunyan
- Alan Slough (born 1947), footballer who played for Luton Town and Fulham
- John P. Slough (1829–1867), American politician and general
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