Subacute cutaneous lupus erythematosus

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Subacute cutaneous lupus erythematosus
Classification and external resources
ICD-10 L93.1
MeSH D008178

Subacute cutaneous lupus erythematosus (SCLE) is a clinically distinct subset of cases of lupus erythematosus that is most often present in white women aged 15 to 40, consisting of skin lesions that are scaly and evolve as polycyclic annular lesions or psoriasiform plaques.[1]

Characteristically the lesions appear in sun-exposed areas such as the vee of the neckline or the forearms, but not the face. It may be brought on by sun-sensitizing medications, but is usually associated with autoimmune disorders such as rheumatoid arthritis and Sjögren's syndrome.[2]

Treatment generally involves sun avoidance/protection and topical corticosteroids.[2] Sometimes systemic drug treatment is necessary. Besides corticosteroids other immunsuppressants such as methotrexate are also used.[3]

Lesions of SCLE may have an annular configuration, with raised red borders and central clearing.[4][5]

See also[edit]

References[edit]

  1. ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. Page 160. ISBN 0-7216-2921-0.
  2. ^ a b Burkhalter NW, McKenzie JT, Lane JE (2009). "Subacute cutaneous lupus erythematosus". Consultant 49 (3). 
  3. ^ Boehm I et al. Management of cutaneous lupus erythematosus with low-dose methotrexate: Indication for modulation of inflammatory mechanisms. Rheumatol Int 1998;18:59 – 62 http://www.ncbi.nlm.nih.gov/pubmed/9782534
  4. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. p. 563. ISBN 1-4160-2999-0. 
  5. ^ Sontheimer RD, Thomas JR, Gilliam JN (December 1979). "Subacute cutaneous lupus erythematosus: a cutaneous marker for a distinct lupus erythematosus subset". Arch Dermatol 115 (12): 1409–15. doi:10.1001/archderm.1979.04010120007006. PMID 533284.